Associate Principal Scientist - Development Metabolism

JOB OVERVIEW

The Associate Principal Scientist builds on experience, skills and personal attributes of an accomplished bioanalytical and/or identification scientist and requires the ability to act independently with little or no guidance. The position involves applying analytical skills in the development and implementation of biotherapeutic assays of different molecular modalities including small molecule and large molecule therapeutics (peptides, proteins, mAb, ADC, siRNA, Oligonucleotide, etc.). An advanced understanding of chromatography and modern high resolution orbitrap mass spectrometry instrumentation, development/validation of methodology, biological sample preparation, interpretation of data, interaction with clients, and working to objectives/timelines are integral to this position.

RESPONSIBILITIES:

• Design and execute large molecule bioanalytical and identification studies (PTMs, de novo) of different scaffolds (peptides, proteins, oligonucleotides, mAbs. ADCs etc) and support of drug discovery and development studies.
• Demonstrate laboratory expertise with large molecule biologic assays (skills in protein purification and characterization, mammalian tissue processing, cell-based assays etc.) aimed at drug discovery and development.
• Develop methods including sample preparation, chromatography and mass spectrometry approaches for the detection and quantitation of compounds; work with Thermo and Waters HRMS platforms.
• Communicate with clients regarding progress on scientific and operational objectives.
• Work with management to set work plans, goals and metrics to build this service.
• Prepare and presents project data and supporting information. Contributes to and reviews technical reports.
• Attends scientific meetings and client visits to promote organization's LCMS Biologics business.
• Train less experienced scientific co-workers, when necessary, to support growth of LCMS Biologics service.
• Oversee daily management of intra- and inter-organizational relationships to ensure timely completion of projects in accordance with customer specification.
• Provide frequent communication of project status with clients.
• Work with the project leader or senior leader to design & execute study strategy, maintain study schedule and focus to produce quality deliverables.
• Work with key clients to implement this service in accordance with their expectations.

MINIMUM REQUIRED EDUCATION AND EXPERIENCE:

• Bachelor's Degree in Chemistry/Biochemistry/Pharmacy or a related field with at least 8 years' progressively responsible related experience OR
• Master's degree with at least 5 years or equivalent combination of education OR
• Ph.D. is preferred with at least 3 years' experience.

REQUIRED KNOWLEDGE, SKILLS AND ABILITIES:

• Understanding of chromatography and mass spectrometry instrumentation.
• Understanding of all routine laboratory procedures.
• Understanding of development/validation of methodology.
• Understanding of wet-laboratory sample extraction.
• Ability to interact with clients, and work to objectives/timelines.
• Excellent attention to detail and communication skills.
• Ability to maintain clear and efficient method development documentation.
• Ability to provide verbally communicated or draft procedures.
• Advanced understanding of nano-flow chromatography and modern quadrupole or orbitrap mass spectrometry instrumentation, development/validation of methodology, biological sample preparation, interpreting of data.
• Ability to establish and maintain effective working relationships with coworkers, managers and clients.

PHYSICAL REQUIREMENTS:

• Extensive use of keyboard requiring repetitive motion of fingers.
• Extensive use of telephone and face-to-face communication requiring accurate perception of speech.
• Regular sitting for extended periods of time.

Q² Solutions, IQVIA's laboratory business, creates connected intelligence by combining our expertise, technology and analytics - this fuels unparalleled research & development solutions. We uphold a deep commitment to patients, sites, customers, and each other. https://www.q2labsolutions.com/careers

We are committed to providing equal employment opportunities for all, including veterans and candidates with disabilities. https://jobs.iqvia.com/q2-solutions-eoe

Q² Solutions' ability to operate and provide certain services to customers and partners necessitates Q² Solutions and its employees meet specific requirements regarding COVID-19 vaccination status. https://jobs.iqvia.com/q2-solutions-covid-19-vaccine-status