Group Leader, Bioconjugation

Catalent Pharma Solutions at our Emeryville, CA location is seeking a Group Leader, Bioconjugation who will be responsible for leading the conjugation , purification, analysis, and optimization of site-specific antibody-drug conjugates (ADCs). This position reports to Head of R&D Bioconjugates.

This is a full-time position, Monday - Friday, days.

Catalent Pharma Solutions is the leading provider of pharmaceutical development services, drug delivery technologies, manufacturing, packaging, and product commercialization services to the global pharmaceutical and biotechnology industry. We employ over 19,000 people in more than 50 facilities worldwide with reported annual revenues of approximately $4 billion. At Catalent, we take pride in providing a shared commitment to build employee capability, and foster a culture of inclusion, where talent and potential are unleashed, and where employees are committed and engaged to achieve results.

Catalent Biologics Emeryville, CA site, formerly the startup company Redwood Bioscience, has developed a proprietary approach for site-specific bioconjugation to produce next-generation antibody-drug conjugates (ADCs). This technology, termed SMARTag®, is based on use of the aldehyde-tag site-specific protein modification technology and Catalent's novel conjugation chemistry and proprietary, stable linkers. SMARTag is a clinical-stage technology that was named Runner Up for Best Platform at the 2022 World ADC Awards in San Diego, CA. The Catalent Biologics Emeryville site comprises a close-knit team of scientists working cross-functionally with each other to nimbly achieve our goals and milestones. We are a research site, working to develop therapeutic ADC drug candidates for clinical testing. We also continuously strive to improve and expand our technology platform. The team has a focus on publishing papers and filing intellectual property to contribute to the exciting and dynamic field of bioconjugation and drug conjugates.

This position is based in Emeryville, CA, 94608 in the EmeryStation West campus, at 5959 Horton St., easily accessible by BART / EmeryGoRound, AMTRAK, or car (with private, secured, on-site parking provided).

Catalent is committed to a Patient First culture through excellence in quality and compliance, and to the safety of every patient, consumer, and Catalent employee.

The Role:

• Oversee antibody-drug conjugation, purification, and analysis to support partner and internal programs.
• Coordinate production timelines by working closely with upstream (Protein Science and Chemistry) and downstream (Biocharacterization) teams to ensure on-time delivery of requested materials.
• Ensure expected product quality, including meeting target DAR, monomeric purity, and endotoxin levels.
• Mentor direct reports, ensure that they learn, grow, and are engaged in the site's work.
• Represent the site in customer-facing meetings, and interface with the broader scientific community through publications and presentations at scientific conventions.
• Set a culture of achievement that is execution and results oriented.
• Identifying and enabling novel therapeutic applications for aldehyde tag technology.
• Interfacing with internal and external stakeholders as a leader representing our site and SMARTag business. This includes presenting data both at professional conferences and in private meeting settings.
• All other duties as assigned.

The Candidate:

• Requires a Bachelors of Science in Biology, Chemistry, or a related discipline with 12+ years of industry experience; OR a Masters Degree in Biology, Chemistry, or a related discipline with 8+ years of industry experience; OR a PhD in Biology, Chemistry, or a related discipline with 5+ years of industry experience.
• Must have significant experience with antibody-drug conjugation, ADC purification and analysis.
• Experience with bioconjugation of high potency bioactive molecules is required.
• Demonstrated expertise in the optimization of ADC bioconjugation, bioconjugate purification, and concentration. Formulation experience a plus.
• Chromatography expertise (FPLC and HPLC) required.
• Ability to perform HIC and SEC analyses and interpret results required.
• Diafiltration (TFF) expertise required.
• Strong organizational skills, with demonstrated experience in project goal/milestone setting, timeline tracking, and coordinating on-time deliverables is needed. Experience working across broad functional teams a plus.
• Track record of success as an individual contributor in a biopharmaceutical company. Evidence of leadership skills (as shown through people or project management or other site responsibilities) is required.
• 5+ years of experience managing projects strongly desired, but must be able to manage project performed at CROs.
• Physical requirements: must be able to sit/stand/walk regularly with use of computers/phones on a daily basis. Must be able to lift up to 15lbs.

Pay:

• The anticipated salary range for this role in Emeryville, CA is $148,000 to $170,000 annually. The final salary offered to a successful candidate may vary, and will be dependent on several factors that may include but are not limited to: the type and length of experience within the job, type and length of experience within the industry, skillset, education, business needs, etc. Catalent is a multi-state employer and this salary range may not reflect positions that work in other states.

Why you should join Catalent:

• Awesome team collaboration
• Defined career path and annual performance review and feedback process
• Diverse, inclusive culture
• Several Employee Resource Groups focusing on D&I
• 19 days of PTO + 8 paid holidays
• Dynamic, fast-paced work environment
• Positive working environment focusing on continually improving processes to remain innovative
• Potential for career growth on an expanding team within an organization dedicated to preserving and bettering lives
• Competitive salary with bonus potential
• Community engagement and green initiatives
• Generous 401K match and Paid Time Off accrual
• Medical, dental and vision benefits effective day one of employment
• Tuition Reimbursement - Let us help you finish your degree or earn a new one!
• GymPass program to promote overall physical wellness
• Perkspot - offers exclusive or private discounts from approximately 900+ merchants in a wide array of categories

Catalent offers rewarding opportunities to further your career! Join the global drug development and delivery leader and help us bring over 7,000 life-saving and life-enhancing products to patients around the world. Catalent is an exciting and growing international company where employees work directly with pharma, biopharma and consumer health companies of all sizes to advance new medicines from early development to clinical trials and to the market. Catalent produces more than 70 billion doses per year, and each one will be used by someone who is counting on us. Join us in making a difference.

Catalent is committed to the health and safety of its employees, visitors and the customers and patients we serve. As a result of the global pandemic, we have modified many of our recruitment and on-boarding processes to maintain everyone's safety. The Human Resources teams will communicate all necessary safety processes and procedures throughout each stage.

personal initiative. dynamic pace. meaningful work.

Visit Catalent Careers to explore career opportunities.

Catalent is an Equal Opportunity Employer, including disability and veterans.

If you require reasonable accommodation for any part of the application or hiring process due to a disability, you may submit your request by sending an email, and confirming your request for an accommodation and include the job number, title and location to [email protected]. This option is reserved for individuals who require accommodation due to a disability. Information received will be processed by a U.S. Catalent employee and then routed to a local recruiter who will provide assistance to ensure appropriate consideration in the application or hiring process.

Notice to Agency and Search Firm Representatives: Catalent Pharma Solutions (Catalent) is not accepting unsolicited resumes from agencies and/or search firms for this job posting. Resumes submitted to any Catalent employee by a third party agency and/or search firm without a valid written & signed search agreement, will become the sole property of Catalent. No fee will be paid if a candidate is hired for this position as a result of an unsolicited agency or search firm referral. Thank you.

Important Security Notice to U.S. Job Seekers:

Catalent NEVER asks candidates to provide any type of payment, bank details, photocopies of identification, social security number or other highly sensitive personal information during the offer process, and we NEVER do so via email or social media. If you receive any such request, DO NOT respond- it is a fraudulent request. Please forward such requests to [email protected] for us to investigate with local authorities.

California Job Seekers can find our California Job Applicant Notice HERE.