Postdoctoral Fellow - RNA Splicing Dysregulation, DNA Damage Response, and Oncogenesis in Blood Malignancies

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Wang Laboratory at the Department of Systems Biology, Beckman Research Institute, City of Hope, is seeking for a talented and motivated Postdoctoral Fellow to lead the project for RNA splicing dysregulation, DNA damage response, and oncogenesis in blood malignancies. Candidates with strong background in RNA splicing, DNA damage, cancer biology, animal models, and bioinformatics are encouraged to apply. Wang Laboratory is currently funded by two R01 grants, foundation grants, and City of Hope Startup package.

Lab Publications:

Yin SY, Gambe R, Brooks AN, Sun J, Fan J, Seiler M, Obeng E, Zhang W, Wan Y, Cibulskis CL, Neuberg D, Buonamici S, Smith PG, Campagna D, Meyerson MM, Fleming MD, Ebert BJ, Carrasco RD, Wu CJ, Wang L. A murine model of chronic lymphocytic leukemia based on B cell-restricted expression of Sf3b1 mutation and Atm deletion. Cancer Cell. 2019, 35: 283-296

Wang L , Brooks AL, Fan J, Wan Y, Gambe R, Li S, Hergert S, Freeman SS, Levin JZ, Fan L, Seiler M, Buonamici S, Smith PG, Chau KF, Cibulskis CL, Zhang W, Rassent LZ, Ghia EM, Kipps TJ, Fernandes S, Bloch DB, Kotliar D, Landau DA, Shukla S, Aster JC, Reed R, DeLuca DS, Brown JR, Neuberg D, Getz G, Livak KJ, Meyerson MM, Kharchenko PV, Wu CJ. Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia. Cancer Cell. 2016 30(5): 750-763. PMC5127278

Wang L , Fan J, Francis J, Zhang C, Herger S, Gambe R, Li S, Zhou C, Yang C, Xiao S, Dal Cin P, Bowden M, Kotliar D, Shukla S, Brown JR, Neuberg D, Livak KJ, Kharchenko PV, Wu CJ. Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res 2017 27 1-13

Basic education, experience and skills required for consideration:

• An M.D. or Ph.D. degree in hematology, molecular biology, cancer biology, or a related discipline is required
• Understanding fundamental mechanism of DNA damage is required
• Knowledge in transcriptome analysis is preferred
• Familiar with genetic murine models is preferred
• Excellent verbal and written communication skills
• Self-motivated, independent and creative

Additional Information:

• For consideration, please directly send a CV, a brief statement of scientific research interests, contact information for at least two references and start date availability to: [email protected] .
• For detail laboratory information, please visit: https://www.cityofhope.org/research/systems- biology/systems-biology-research-labs/lili-wang-lab . Twitter: https://twitter.com/LiliWangLab

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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• Posting Date: Jan 13, 2021
• Job Field: Research
• Employee Status: Regular
• Shift: Day Job