Postgraduate Cell and Gene Therapy (AAV)

Summary

We are seeking a highly motivated postgraduate student with enthusiasm for AAV productions to join our dynamic and experienced cell and gene therapy team for a 10-month internship. This position resides in the Cell and Gene Therapy (CGT) group within Biologic Research Center (BRC) in Basel, Switzerland.

Adeno-associated virus (AAV) have become popular for safe and efficient gene therapies, however capsid modifications are crucial to enhance specificity and to reduce immune responses. Our AAV capsid engineering team is developing, screening and ranking novel capsids. This Postgraduate role will support our technology development by setting up a small-scale AAV production, purification and screening workflow that is contributing to the development of novel AAV vectors.

Please attach a cover letter explaining your motivation.

Preferred start date: March 1st 2025
Duration: 10 months

About the Role

Major accountabilities:

• Perform small-scale AAV productions (24-deep well format)
• Establish and compare several AAV purification methods followed by analytics
• Screening and ranking of AAV candidates in cell culture assays using flow cytometry or luciferase readout
• Collect, analyze and document (using electronic lab book) experimental data
• Presenting protocols and results in internal lab group meetings

Minimum Requirements:
Work Experience:

• Hands-on experience in cell culture techniques (suspension or adherent cell lines and transfection methods)
• AAV or protein production and purification experience is a strong plus
• Knowledge in screening techniques such as Flow cytometry or Luciferase readout

Skills:

• Recent master graduate (no longer than 1 year ago) with a degree in Virology, Life Sciences, Biology, Molecular Medicine, Biotechnology or related disciplines

Languages :

• English

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Commitment to Diversity and Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Accessibility and accommodation

Novartis is committed to working with and providing reasonable accommodation to all

individuals. If, because of a medical condition or disability, you need a reasonable

accommodation for any part of the recruitment process, or in order to receive more detailed

information about the essential functions of a position, please send an e-mail to

[email protected] and let us know the nature of your request and your

contact information. Please include the job requisition number in your message

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Division
Biomedical Research

Business Unit
Pharma Research

Location
Switzerland

Site
Basel (City)

Company / Legal Entity
C028 (FCRS = CH028) Novartis Pharma AG

Functional Area
Others

Job Type
Full time

Employment Type
Early Career (Fixed Term)

Shift Work
No