Scientist (Contractor)

Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy. 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Scientist (Contractor) as part of the US R&D team based in Piscataway, NJ. 

Role Overview

We are seeking a highly motivated and creative scientist to grow our pipeline efforts. The successful candidate will be part of Legend Biotech, a leading cell therapy company with commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our R&D team, whose aim is to research, develop and advance the next generation cell therapies using cutting edge genome editing technologies and create innovative novel CAR designs for a wide range of human indications. The position requires enthusiasm, passion, outstanding skills in the art, attention to detail, and a desire to create new medicines for patients.

Key Responsibilities  

• Be able to work independently under minimal supervision.
• Lead, design and optimize research with aims of exploring next generation cell therapies using CRISPR based 
  genomic editing.
• Help current efforts on CRISPR screening projects and perform functional characterization of gene knockout T 
  cells using multiple functional assays but not limited to cytotoxicity assay, serial cytotoxicity assay, cytokine 
  release assay and mixed lymphocytic reaction (MLR) etc.
• Design, execute and interpret research requiring molecular biology techniques including PCR/DD-PCR/qPCR, 
  NGS, RNA and DNA analysis.
• Perform research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based 
  assays.
• Analyze and present data to a wide range of audiences of internal group meetings and other forums.
• Dissect published literature to find novel solutions to cell therapy problems.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner.

• PhD in Biology or related discipline.
• Experience with Cell culture methods (T cells, CAR-T or TCR-T preferred), CRISPR based gene knockout, quantitative PCR and functional characterization of knockout T cells (Cytotoxicity assay using Incucyte or xCelligence, and MLR assay).
• Prior experience with CRISPR functional screening will be preferred.
• Proficient in cell-based assays with various read out technologies 
  such as flowcytometer, Incucyte, Xcelligence.
• Experience with transfection and lentivirus or retrovirus 
  transduction.
• Experience/ working knowledge (molecular biology and cellular 
  biology) in characterizing CRISPR based gene knockout.
• Individual should be go-getter and be able to work 
  independently.
• Excellent written and oral communication skills.

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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.