Scientist I/II, Nanoparticle Formulations

About Sail:

The Role:

Sail Biomedicines is seeking a highly motivated Scientist I/II to join our mission of developing novel programmable delivery technology. This is a unique opportunity to be an integral part of a team dedicated to creating a transformative delivery platform for precision targeting of therapeutics. Your contributions will play a crucial role in testing and further training advanced AI/ML models. This position offers the chance to excel in your field of expertise while also collaborating with multiple teams across the company.

Responsibilities:

• Design and optimize novel formulations for nucleic acid (mRNA, siRNA, DNA, etc.) delivery, while providing critical input on our overall formulation strategy
• Develop and validate analytical methods for cargo and formulations
• Execute experiments that will serve as the basis for the company’s ongoing platform and intellectual property development
• Develop novel methods to help advance our understanding of nanoparticle mechanism of action, evaluating functionality, targeting efficiency and potency of novel delivery modalities
• Work closely with cross-functional teams across Sail, collaborators, and CROs to progress candidates from discovery through IND-enabling studies.
• Manage multiple experiments, projects, and interactions with supporting functions simultaneously
• Interpret, troubleshoot, and report complex data 

Minimum qualifications: 

• PhD. in Pharmaceutical Science, Chemical Engineering, Biological Engineering, Chemistry, or related discipline, with a demonstrated strong background in developing diverse formulations with in vitro/in vivo applications
• Execution-focused, team-oriented, and highly motivated, with strong work ethic Ability to work independently, manage multiple projects concurrently, and collaborate across disciplines
• Strong verbal, written communication, and problem-solving skills
• Ability to excel in a fast-paced, dynamic, innovative environment 

Strongly preferred qualifications: 

• Experience with in vivo delivery of nucleic acids
• Strong disposition for physicochemical and biophysical analytics, including assay development
• Proficiency in analytical techniques such as differential scanning calorimetry (DSC), TGA, SANS, SAXS, FTIR, HPLC, DSC, Mass spectrometry, DLS, zeta potential, UV-Vis, and fluorescence spectrophotometry, etc. is preferred