Senior Research Associate, Platform R&D
Company
A-Alpha Bio
Location
Seattle, WA
Type
Full Time
Job Description
A-Alpha Bio is an early-stage and rapidly-growing drug discovery company headquartered in Seattle, WA. We are enabling the next generation of high-impact therapeutics by combining high-throughput synthetic biology with state-of-the-art machine learning. We partner with leading pharma and biotech companies to enable the discovery of antibodies, molecular glues, and other protein interaction-related drugs. In parallel, we use our AlphaSeq technology internally to build a Biologics Pipeline for clinical development and/or asset licensing opportunities.
This role is not open to remote applicants and would require relocation to Seattle, WA.
Starting Salary Range: $86,000 - $101,000 per year
Exemption Status: Exempt
Location Expectations: Onsite
Role Description
A-Alpha Bio is seeking an experienced molecular/synthetic biologist to join our R&D team. This role will involve both wet and dry lab activities focused on designing, executing, and optimizing our AlphaSeq platform. From a technical perspective, the role will largely involve designing and building yeast surface display libraries, performing and monitoring experimental assays, and analyzing next-generation sequencing data. Expertise in yeast biology, molecular biology, and next-generation sequencing techniques is required. The ideal candidate will be capable of operating independently, possess strong organizational skills, and enjoy the startup environment.
Responsibilities
- Design and execute projects for internal R&D programs, external partners, collaborators, and funding agencies.
- Design, execute, and analyze optimization experiments on the AlphaSeq platform.
- Work with cross-functional teams to execute and troubleshoot experiments.
- Participate in discussions to determine R&D strategy and define project specifications for internal programs.
- Independently author detailed, accurate, and accessible documentation of experiments and data.
- Present experimental work at cross-functional program team meetings.
- Take advantage of additional opportunities in managing internal and external programs.
- Perform other duties as assigned.
Qualifications
Required
- Bachelor’s degree in a Life Sciences field, with 4+ years of molecular biology experience; or an equivalent combination of education and experience.
- Experience with Gibson Assembly, PCR, and other relevant molecular biology techniques.
- Experience with Oligo and DNA fragment design and ordering.
- Experience with next-generation sequencing (e.g., Illumina, ONT, PacBio).
- Demonstrated experience with troubleshooting.
- Strong communication skills, with the ability to interact with groups in dynamic startup team settings.
Preferred
- Familiarity with flow cytometry, protein-based assays, tissue culture, and/or yeast biology.
- Familiarity with DNA library assays (e.g., surface display, yeast-two-hybrid).
- Data analysis skills.
We offer competitive compensation, including benefits and equity in a fast-growing start-up. Applicants must have legal authorization to work in the United States. At this time, A-Alpha Bio is unable to offer visa sponsorship in any form.
About A-Alpha Bio
A-Alpha Bio is an early-stage biotechnology company combining synthetic biology and machine learning to dramatically improve the discovery of high-impact therapeutics. We believe that abundant high-quality data is critical for understanding biology and curing disease – and synthetic biology is our catalyst. Our proprietary AlphaSeq platform uses genetically engineered cells to quantitatively measure millions of protein interactions – from which we generate high-resolution models of biology.
In 2018, we spun out of the University of Washington’s Institute for Protein Design and Center for Synthetic Biology – both fantastic communities of brilliant and highly entrepreneurial scientists. Since the company’s inception, we have focused on partnering with pharmaceutical companies to discover and optimize drugs for therapeutic areas ranging from infectious disease to cancer. We are growing rapidly, and new members of the team should expect a fast-paced and highly dynamic work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.
A-Alpha Bio is headquartered in a brand-new combined office/lab space in downtown Seattle's Belltown neighborhood. While the startup lifestyle occasionally requires grueling hours, we strongly value the need for a work-life balance and time out of the lab/office. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, and sailing. At A-Alpha, you’ll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio.
Date Posted
11/28/2023
Views
15
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