Advisor- Mass Spectrometry

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Organization Overview:

Lilly, a leading innovation-driven corporation is developing a growing portfolio of pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Indiana, Lilly makes life better - through medicines and information - for some of the world's most urgent medical needs. Founded over 146 years ago, the company has sustained a culture that values excellence, integrity, and respect for people. This has resulted in Lilly frequently being ranked as one of the best companies in the world at which to work. Lilly knows its business has prospered because of its employees - people with a talent for innovation and a passion for making a difference by finding treatments for the most stubborn diseases; people whose talent is matched by their generosity, and people with strong values and a determination to prevail, regardless of the challenges. Join our team - and make a difference in improving health for people all over the world.

The Advisor (Senior Scientist) modernizes and improves the analytical control strategy of protein drug substances. This includes the application of mass spectrometry to improve the current business and support the commercialization of new molecules.

The position is within in the Analytical Sciences organization. The position will be made available beginning Jan 2, 2023 and will provide technical and scientific support within a dynamic manufacturing environment for development of commercial processes (synthesis and purification) for biomolecules including proteins, peptides, and oligonucleotides. The successful candidate will be responsible for designing and executing experiments to advance process knowledge, process optimization and production technical transfer, as needed. Scientists actively contribute to the Analytical Sciences organization, and have extensive opportunities for involvement in cross-functional teams. This position allows for development of a comprehensive understanding of the pharmaceutical industry, Good Manufacturing Practices (GMP), regulatory requirements, and the essential role scientists play in creating solutions for Eli Lilly and Company.

Responsibilities:

• Serve as the subject matter expert for molecule developability, assessment, and physical characterization.
• Identify and support the implementation of new technologies/methods that offer significant advantages in cost reduction or process control. This includes expanding the use of mass spectrometry in a highly regulated environment.
• Responsible for the development, qualification, validation, and transfer of analytical methods.
• Streamline analytical strategies to reduce the overall testing burden in terms of cost and/or time.
• Develop methods to meet unmet control strategy needs.
• Ensure the analytical control strategy from raw materials through drug substance is technically sound, cost effective, compliant, and sustainable.
• Troubleshoot and investigate major analytical issues.
• Align regulatory strategies that require analytical testing with the goal of streamlining and modernizing the analytical control strategy.
• Strong technical writing and documentation of all work in an appropriate manner.
• Mentor lab associates to enhance their technical capabilities.
• Participate in technology transfer as needed.

Basic Requirements:

• PhD in Analytical Chemistry, Biochemistry, or Chemistry or other similar scientific area with 0-2+ years of relevant post-graduate experiences. Industry experience is a plus. Masters degree with 5+ years of experience or Bachelors degree with 10+ years of experience will also be considered.

Additional Skills/Preferences:

• Previous experience working with LC-MS method development, optimization, validation, and execution in GMP analytical testing laboratories
• Experience developing protein/polypeptide analytical chromatography separations
• Practical experience with LC-MS, MS/MS, and HRMS instrumentation
• Strong scientific communication skills
• Demonstrated record of scientific achievement
• Demonstrated problem solving abilities
• Ability to work well independently and collaboratively
• Masters or Doctorate in Chemistry, Biochemistry, or a related field
• Industry related experience in pharmaceuticals is preferred
• Strong statistical skills
• Familiarity with GC/MS

Additional Information:

The position is located in Indianapolis, IN.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [email protected] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

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As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

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