Associate Director, CMC Drug Substance

Recursion is the clinical-stage biotechnology company decoding biology by integrating technological innovations across biology, chemistry, automation, data science, and engineering to radically improve the lives of patients and industrialize drug discovery. Our team is working to solve some of the hardest, most meaningful problems facing human health today. Come join us in our mission to decode biology to radically improve lives, while doing the most impactful work of your life.

We care about our drug candidates, our Recursionauts, their families, each other, the communities in which we live and work, and we care deeply about the patients we aim to serve and their loved ones. We also care about our work; we operate with an owner’s mindset. We care so much that we are willing to do and say the hard things to make each other and the company better. 

The Impact You’ll Make

Recursion Pharmaceuticals is on the cutting edge of drug discovery generating proprietary maps of biology that provide unique insights driving target identification, validation and ultimately novel clinical candidates.  We are seeking an Associate Director, CMC Drug Substance to advance our current and future clinical assets through development and ultimately to patients in need.  In this role, you will:  

• Lead external drug substance development across our portfolio including oversight of CDMOs and strategic technical development relationships 
• Provide technical leadership, project management and oversight of drug substance process development and manufacturing activities supporting Recursion’s clinical programs  
• Ensure delivery of drug substance from external manufacturing campaigns adhering to current quality guidelines and delivery timelines.  Typical travel to external manufacturing sites is 10-20% of the time. 
• Critically analyze process and analytical data to identify and resolve key synthetic challenges during drug substance development 
• Participate in developing and extending our CDMO relationships, budget planning and forecasting for drug substance expenditures and achieving our quality requirements 

Location 

Making Salt Lake City your home base is ideal, however, we will consider remote work for this position. We ask that remote employees commit to regular on-site visits for routine work and departmental events. 

The Team You’ll Join 

As Associate Director, CMC Drug Substance, you will be an essential member of the Recursion CMC Team reporting to the Senior Director, CMC Drug Substance. The CMC Team is an empowered, execution-minded group of scientists and technical experts responsible for translating Recursion’s innovative science to patients in clinic through CMC activities and deliverables. 

The Experience You’ll Need

• Ph.D. in organic chemistry or closely related field with a minimum of 5-8 years experience or M.S. with 8-12 years of experience 
• Strong knowledge and experience in small molecule drug substance process development and manufacturing best practices across all phases of drug development, from initial regulatory filings through registration, validation and launch 
• Prior experience leading external development and CDMO relationships is a plus 
• Demonstration of cross-functional understanding related to drug substance development including salt/polymorph screening, phase appropriate analytical development, standard process of drug product development, quality and regulatory affairs 
• Well-versed in the latest trends impacting drug substance technology, manufacturing  and the outsourcing industry

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