Associate Director/Director, Cheminformatics

Position Summary

Matchpoint Therapeutics is looking for a talented, driven cheminformatician with a proven track record in advancing drug discovery pipelines. The successful candidate will have extensive experience in cheminformatics;  using state-of-the-art deep learning/machine learning (DL/ML) tools in developing models that impact programs. Additional experience is in applying DL/ML techniques to generative molecular designs, use of cheminformatic tools to analyze chemoproteomics data, and in analysis of DEL experiments is highly preferred.

The successful candidate will partner with Matchpoint’s leadership team to develop and execute on a vision and strategy for state-of-the-art cheminformatic tools in covalent small molecule drug discovery. The incumbent will collaborate with multidisciplinary colleagues across the research team, as well as with external scientific domain experts, and have the skills to influence and manage science both internally
and externally.

Key Responsibilities / Essential Functions

• Partner with leadership team to set vision and strategy for cheminformatics as it applies to drug discovery and chemoproteomics platform
• Develop and deploy DL/ML models for drug discovery projects
• Analyze in vitro and ADME properties to inform improved design in covalent drug discovery programs
• Drive molecular design by working closely with internal and external computational chemistry colleagues
• Develop and deploy analysis and visualization tools for medicinal and computational chemists, as well as for chemoproteomics experiments

Qualifications/ Year(s) of Experience / Education Requirements / Competencies

• Ph.D. or equivalent in physical chemistry, organic, computational chemistry, cheminformatics, physics, and/or computer science
• 8+ years of cheminformatics experience in biotech/pharma
• Proven track record of impact and innovation as evidenced by authorship and/or inventorship
• Ability to communicate results and proposals to all levels of the organization and to influence molecule design and med chem program strategy
• Ability to work effectively in a globe-spanning virtual team and adjust priorities as required to meet evolving company needs and deadlines
• Previous experience contributing to covalent drug discovery is desirable