Associate Scientist (Contract)

Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) therapies for cancer. Led by a world-class management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell therapy candidates with the goal of delivering readily available cell therapy faster, more reliably and at greater scale to more patients.

AlloCAR T™ cell therapies are engineered from cells of healthy donors, which is intended to allow for creation of inventory for on demand use in patients. This approach is designed to eliminate the need to create personalized therapy from a patient’s own cells, simplify manufacturing, and reduce the time patients must wait for CAR T cell treatment. The Allogene portfolio includes rights to 16 pre-clinical CAR T cell therapy targets and UCART19, an AlloCAR T™ therapy candidate currently in Phase 1 sponsored by Servier for the treatment of relapsed/refractory acute lymphoblastic leukemia (ALL). For more information, please visit www.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.

Job Description

We are seeking a highly motivated Associate Scientist/Scientist to join our Analytical Development group and contribute to the commercialization of allogenic CAR T therapies. (S)he will play a key role in CAR T cell therapy related analytical assay development and execution of drug product release and characterization assay.

The individual will work closely with peers in assay development, assay qualification, execution of the release and characterization assays, comprehensive risk assessments, and data synthesis that allows for the subsequent analytical assay tech transfer. This role will be based at the headquarters in South San Francisco, CA.

Responsibilities include, but are not limited to:

• Mammalian cell culture.
• Primarily execute analytical test methods involving cell-based and/or immunoassays and molecular biology techniques.
• Assist in analytical method optimization, development, and qualification in support of product and process development and product characterization.
• Document standard operating procedures and experiments, using an electronic laboratory notebook (ELN) with great attention to detail.
• Coherently summarize and communicate experiments and findings.
• Work collaboratively with cross-functional teams to meet deadline-dependent milestones and advance the development of Allogene’s CAR T programs.
• Maintain, calibrate, and operate analytical instruments.
• Maintain sample inventories.
• Other duties as assigned.

Position Requirements & Experience:

• Masters, or bachelors with 3 years of relevant cell biology, immunology or biochemistry experience.
• Ability to work independently and as part of a team.
• Experience with cell culture, cell banking, and aseptic technique is required.
• Prior working knowledge of nucleic acid isolation, quantification, and PCR is preferred.
• Prior working knowledge in ELISA, FACS a plus.
• Experience with data analysis tools such as Prism, FlowJo and Microsoft Excel a plus.
• Working knowledge of quality control and assay qualification is a plus.
• Self-motivated, organized and detail-orientated, with a positive “can-do” attitude towards assigned tasks is expected.
• Candidates must be authorized to work in the U.S.

We offer a chance to work with talented people in a collaborative environment and provide a top-notch compensation and benefits package, which includes an annual performance bonus, equity, health insurance, generous time off (including 2 annual holiday company-wide shutdowns) and much more. The expected salary range for this role is $35 to $40 an hour. Actual pay will be determined based on experience, qualifications, geographic location, business needs, and other job-related factors permitted by law.

As an equal opportunity employer, Allogene is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment and internships designed to create a stronger and better Allogene that is focused on developing life-changing products for patients.

Please be aware that the FBI recently issued a warning about an increased number of fake job postings for remote work employment that target applicants' personally identifiable information. All approved Allogene Therapeutics positions are accessible via the Allogene Careers page at www.allogene.com/careers