Associate Scientist I/II, Process Development
Job Description
We make healthy cells invisible to targeted therapies
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively invisible to targeted therapies. Diseased cells displaying the target protein and are then vulnerable to attack. This process potentially broadens the therapeutic window and improves the utility of complementary targeted therapies.
What we value in our fellow Voracians
Passion:Â Enthusiastically driving our science toward innovative medicines
Fellowship:Â Fostering genuine bonds of collaboration and mentorship
Humility:Â Acting selflessly by putting the collective mission first
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Who we are looking for:
Vor Bio is seeking a motivated Associate Scientist I/II to join our Process Development team. This candidate will help drive the development of innovative cell therapy products and platforms, focusing on gene-edited hematopoietic stem cells.
As an integral part of the Process Development team, this role focuses on developing the manufacturing process for cell therapy products in the immune-oncology space. The successful candidate will plan experiments and generate data to help Vor's leadership make decisions on designing and manufacturing current and future cell therapy products.
Working within an interdisciplinary team, the Associate Scientist I/II would gain exposure spanning from Research, CMC, and Regulatory, to GMP Manufacturing, including exposure to external CMOs and CROs within the space.
Key areas of responsibilities:
- Perform primary human cell isolation, gene-editing, and culture
- Write SOPs and keep batch records
- Analyze and visualize experiment data
- Present study designs and results to internal and external stakeholders
- Work closely with the analytical team to develop and perform characterization assays
- Identify, test, and implement novel cell processing devices and technologies
Skills and requirements:Â
- Bachelor’s degree with 0-1 year of experience (New graduates with co-op experience encouraged to apply)
- Ability to work collaboratively in a team environment and to consistently deliver exceptional results
- Excellent problem-solving and communication skills
- Structured, creative, and action-oriented mindset
- Experience in mammalian cell culture is required
- Experience using analytical/statistical software, such as GraphPad Prism, is preferred
- Experience in developing manufacturing processes for cell therapy product is preferred
- Experience with hematopoietic stem cell isolation, culture, and gene-editing is preferred
- Understanding of cGMP requirements and previous experience in technology transfer is preferred
By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
Date Posted
08/02/2023
Views
4
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