Associate Scientist I/II, Process Sciences
Job Description
We make healthy cells invisible to targeted therapies
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively invisible to targeted therapies. Diseased cells displaying the target protein and are then vulnerable to attack. This process potentially broadens the therapeutic window and improves the utility of complementary targeted therapies.
What we value in our fellow Voracians
Passion:Â Enthusiastically driving our science toward innovative medicines
Fellowship:Â Fostering genuine bonds of collaboration and mentorship
Humility:Â Acting selflessly by putting the collective mission first
Â
Who we are looking for:
Vor Bio is seeking a highly motivated Associate Scientist I/II to join the Process Science Team. In this role, you will evaluate early CART development programs by establishing the base process and assessing CAR phenotype and functionality. You will also work towards expanding our CART platform, to advance VORs targeted cancer immunotherapy approach. The successful candidate will have a background in cell/ molecular biology, bioengineering or immunology with experience working with mammalian cell cultures. Success in this position will require both the ability to independently execute lab experiments and to collaborate cross functionally. This role is an exciting opportunity to join a highly collaborative team in a startup environment.
Key areas of responsibility:
- Establish the base CAR-T process for early development programs and evaluate CART phenotype and functionality respectively
- Work towards improving and expanding on the CAR-T platform
- Characterize CAR-T cells with cell-based assays: flow cytometry, Luminex, cytotoxicity assays
- Expand on existing CAR-T assessment strategies
- Independently generate and execute on experimental plans
- Analyze data and effectively communicate results
- Work collaboratively with other team members to achieve project goals
- Maintain laboratory records and ensure compliance with laboratory protocols and safety procedures
Qualifications:
- Bachelor’s Degree in biology, bioengineering, immunology or related field is required
- 1+ years relevant work experience in an academic or industry setting
- Experience with mammalian tissue culture
- Experience with flow cytometry and cell based assays is preferred
- Prior immunology experience, including T cell biology and chimeric antigen receptors is preferred
- Ability to independently perform lab-based responsibilities with limited guidance
- Strong problem-solving skills and the ability to work independently as well as in a group settings
- Self-motivated with excellent organizational and time management skills is required
- Immediate availability
By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
Date Posted
08/03/2023
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5
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