Associate Scientist, LNP Discovery

Company Overview

Strand Therapeutics is an early-stage biotechnology company utilizing synthetic biology to genetically program mRNA to deliver truly revolutionary immunotherapies.

Building on the idea of creating smart therapies based on Boolean logic circuits, Strand was started by biological engineers working together at MIT who were seeking to apply the concept of the emerging field of mRNA therapeutics. This collaboration led them to build their own mRNA “programming language,” creating the world’s first platform for mRNA smart therapies.

The founders and scientific advisors of Strand Therapeutics are made up of well-known and highly regarded individuals in both academia and the biotech industry. Our corporate headquarters is located in the Fenway district of Boston, Massachusetts with an additional site based in Watertown, Massachusetts.

Become the next standout single strand!

Job Summary:

Strand is looking to build a team that understands the value of working at a start-up. Joining the company now means having vast opportunities to learn and grow including having the exposure to all aspects of building a company. We are looking for people who have the enthusiasm and motivation to be a highly contributing member of a small team. This opportunity will offer the employee the ability to work closely with the founding team, as well as to form close partnerships with team members during the development and formation of the company.

We are looking for a highly motivated and innovative candidate for the role of Associate Scientist, LNP Discovery. The expectation is that the candidate will have experience in the formulation and characterization of LNPs. The candidate will be expected to work in an innovative, fast-paced, cross-collaborative biotech environment and contribute in multi-disciplinary team activities to advance our platform. This role will have the opportunity to collaborate with functions outside of LNP Discovery such as Translational biology, LNP Process Development, and Analytical Development.

Primary Responsibilities:

• Help advance Strand’s mRNA delivery platform and capabilities.
• Contirbute to LNP design, engineering and process screening.
• Characterize the physiochemical properties of LNPs and components using standard or newly developed in-house assays.
• Evaluate the delivery capabilitiy of LNPs using standard or newly developed cell-based assays.
• Execute high throughput LNP screening assays.
• Compule data reports and communicate the results with relevant teams(s).
• Produce LNP formulations to support internal and partnered programs.
• Research and identify new opportunities and novel project ideas related to mRNA delivery that support Strand’s vision.
• Write study protocols, technical reports and SOPs that support the drug discovery efforts of Strand.

Qualifications:

• B.S. or M.S. in Pharmaceutical Sciences, Biomedical Engineering, Chemical Engineering or other relevant scientific disciple.
• 1-3+ years of experience with a focus on LNP in vitro/in vivo delivery formulations with nucleic acid-based payloads is desirable.
• Experience with production and analytical characterization of mRNA LNPs (DLS measurement, RiboGreen assay, luciferase assay etc.).
• Experience with mammalian cell culture and cell-based assays is highly preferred.
• Familiarity with high throughput screening of mRNA LNPs would be a plus.
• Excellent knowledge of the scientific literature in the field of mRNA delivery.
• Highly analytical, decisive, and goal-oriented while maintaining the highest scientific and ethical standards.
• Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment.
• A strong team player with excellent oral and written communication skills and a demonstrated ability to work independently.

Strand offers a fast-paced, entrepreneurial, team-focused work environment. We also offer a top-notch benefits package (health, dental, life, vacation, 401k, and commuter) and work/ life integration. Being part of the Strand team allows you to become part of a small team that supports professional development while working together to meet the company goals.

Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates.

Job Type: Full-time

Salary: Commensurate with role and experience