Associate Scientist, Process Development

Role Summary

Reporting to the Director, Process Development, this position will be responsible for developing and optimizing the production of AAV products in the lab and with collaborators with the goal of advancing the development of novel targets for cardiac and neurodegenerative disorders. As an early hire at a new company, you will have exposure to senior management, and you will be influential in championing and developing LEXEO’s culture. You will have an opportunity to learn in a fast-paced startup company, while working collaboratively within a multidisciplinary team that is dedicated to the development of new therapies.

Location

LEXEO Office located in New York, NY

Primary Responsibilities

• Perform process development, process characterization and scale-up activities to enable high productivity, scalable and robust upstream processes for viral vector manufacturing.
• Serve as a subject-matter-expert for the upstream process development of viral vectors using stirred-tank bioreactor technologies.
  and/or
• Serve as a subject-matter-expert for the downstream process development of viral vectors using chromatographic technologies.
• Design and execute laboratory studies to evaluate novel technologies to improve existing processes and establish manufacturing platforms.
• Engage in proactive relationships with partners including CMO/manufacturing team, a person in a plant, batch record/SOP review.
• Collaborate closely with the analytical team to evaluate critical gene therapy product characterization, critical quality attributes and process performance parameters, product characterization, and product release for gene therapy AAV vector production.
• Prepare manufacturing process data summary, process description, process report, and technology transfer reports.
• Assist with execution of process planning and resourcing critical material to ensure project progress aligns with company timeline.
• Familiar with applicable regulatory cGMP requirements for gene therapy.

Required Skills & Qualifications

• BS/MS degree with 0-2+ years of relevant experience in Chemical Engineering, Biochemical Engineering, Biomedical Engineering, Biotechnology, Biochemistry, Microbiology, or related fields
• Hands-on experience of upstream cell culture processes and stirred-tank bioreactor technologies to manufacture biologics or viral vectors or vaccines.
  and/or
• Hands-on experience of downstream processes and chromatographic technologies to manufacture biologics or viral vectors or vaccines.
• Excellent communication and presentation skills, capable of conveying complex technical information in a clear, thorough, and influential manner is required.
• Excellent MS Office skills with a specific focus on word, excel and power point applications to author technical reports and presentations.

Depending on qualifications and overall experience, base salary is likely to be $75,000-$85,000 per year.

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.