Associate Scientist/Scientist, CPD

Company

Adverum Biotechnologies

Location

Peninsula

Type

Full Time

Job Description

Adverum is looking for an AAV Platform development Associate Scientist/Scientist I with knowledge of Molecular and Cell Biology to join our team in our Redwood City office. This individual will work on developing AAV processes & optimization to be applied to support the AAV production team within the group. This lab-based role will work closely with other scientists, functional teams in the research, and the non-clinical group and collaborators to support AAV production, molecular biology, and pipeline project needs. The Scientist I must have a strong scientific background, be well versed with sterile cell culture and molecular biology techniques, be proactive, must have the ability to balance multiple projects and collaborate with senior and junior scientists. 

What you'll do:

  • Plan and perform experiments to improve AAV product yield in the process development and optimization using suspension cell culture systems, such as shake flasks, and small bioreactors.
  • Evaluate small-scale cell culture experiments to develop and validate scale-down process
  • model supporting production-scale bioreactor optimization.
  • Analyze and interpret experimental results to suggest changes and/or add experiments to
  • improve AAV production yield with the process robustness and/or reproducibility.
  • Design and execute protocols, assembling data, and drafting appropriate technical
  • documentation including SOPs and Process Development Reports.
  • Support early-stage discovery efforts and new target identification by performing data
  • analysis of in vitro cellular assays using various techniques and assays such as
  • DNA/RNA/protein isolation from cells, RT-PCR, qPCR, ddPCR, ELISA, and Western blot.
  • Maintain plasmid and Bacmid records and inventories accurate and up to date.
  • Other responsibilities may be assigned as needed. 

About you:

  • PhD in Cell Biology, Molecular Biology, Virology, Biochemistry or related field and 1-2 years
  • relevant biotechnology industry experience Or Associate Scientist: Bachelors in Cell Biology, Molecular Biology, Virology, Biochemistry or related field and 5-8 years of relevant biotechnology industry experience
  • Strong skills with mammalian HEK293 and insect Sf9 cell culture.
  • Hands-on experience in upstream bioprocess unit operations including shaker flasks, and/or
  • small & large-scale bioreactors strongly needed.
  • Experience with AAV viral vector production for Gene Therapy is preferred.
  • Experience with NGS is a plus.
  • Critical thinking, analytic skills, and trouble-shooting ability.
  • Meticulous attention to detail and strong record-keeping skills.
  • Capability to multi-task, be independent, self-motivated, as well as work in a highly
  • collaborative setting.
  • Excellent oral and written communication skills. 

About Us
Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum’s core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.

At Adverum, Inclusion and Diversity are at our core. We believe in the power of being your authentic self. We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation


Apply Now

Date Posted

09/28/2023

Views

7

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