Associate Scientist/Scientist, CPD
Company
Adverum Biotechnologies
Location
Peninsula
Type
Full Time
Job Description
What you'll do:
- Plan and perform experiments to improve AAV product yield in the process development and optimization using suspension cell culture systems, such as shake flasks, and small bioreactors.
- Evaluate small-scale cell culture experiments to develop and validate scale-down process
- model supporting production-scale bioreactor optimization.
- Analyze and interpret experimental results to suggest changes and/or add experiments to
- improve AAV production yield with the process robustness and/or reproducibility.
- Design and execute protocols, assembling data, and drafting appropriate technical
- documentation including SOPs and Process Development Reports.
- Support early-stage discovery efforts and new target identification by performing data
- analysis of in vitro cellular assays using various techniques and assays such as
- DNA/RNA/protein isolation from cells, RT-PCR, qPCR, ddPCR, ELISA, and Western blot.
- Maintain plasmid and Bacmid records and inventories accurate and up to date.
- Other responsibilities may be assigned as needed.Ā
About you:
- PhD in Cell Biology, Molecular Biology, Virology, Biochemistry or related field and 1-2 years
- relevant biotechnology industry experience Or Associate Scientist: Bachelors in Cell Biology, Molecular Biology, Virology, Biochemistry or related field and 5-8 years of relevant biotechnology industry experience
- Strong skills with mammalian HEK293 and insect Sf9 cell culture.
- Hands-on experience in upstream bioprocess unit operations including shaker flasks, and/or
- small & large-scale bioreactors strongly needed.
- Experience with AAV viral vector production for Gene Therapy is preferred.
- Experience with NGS is a plus.
- Critical thinking, analytic skills, and trouble-shooting ability.
- Meticulous attention to detail and strong record-keeping skills.
- Capability to multi-task, be independent, self-motivated, as well as work in a highly
- collaborative setting.
- Excellent oral and written communication skills.Ā
Date Posted
09/28/2023
Views
7
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