Associate/Senior Associate Scientist, Screening Platform

Position Overview:

The Screening Platform is seeking an experienced, driven, and energetic Associate Scientist/Senior Associate Scientist well versed in high-throughput screening, automation, and NGS-based workflows. The candidate will join our dynamic team to support the implementation of fully integrated, end-to-end, walk-away automation systems to drive the development, execution, and analysis of RNA guide screens in support of therapeutic. The methods, tools and data produced by the candidate will play a critical role in enabling the creation of next-generation gene editing technologies. As a member of our team, the candidate can expect to join a fast-paced, exciting, and collaborative environment.

Key Responsibilities:

• Validate and implement walk-up and fully integrated methods for automation systems
• Design, execute and troubleshoot high-throughput screens in immortalized and primary cells through the application of a variety of genetic perturbation methods.
• Provide key input and contributions that drive scientific strategy and shape future therapies and technologies.
• Assist in the design and assembly of molecular reagents and the development and maintenance of immortalized and primary cell cultures.
• Document, present, and communicate scientific findings to stakeholders.
• Present findings to internal teams and represent Prime at external forums

Qualifications/Requirements:

• A BS or MS in Biology/Engineering or related discipline with ideally 2+ years of experience with molecular biology, biochemistry, or genome editing
• Hands-on experience with high-throughput screening and/or liquid handling automation
• Experience with Tecan FluentControl
• Proficient in aseptic cell culture techniques, mammalian cell culture
• Excellent troubleshooting and communication skills; ability to work independently within a team
• Experience with cloning (primer design, vector construction, Gibson, golden gate, site-directed mutagenesis, etc.) and nucleic acid purification
• Familiarity with screening methodologies and automation of screening is a plus
• Familiarity with library preparation for next-generation sequencing and NGS analysis.