Data Scientist, Translational Data Science (Principal Scientist)

We are seeking a highly motivated, flexible hands-on Data Scientist (Principal Scientist) to join our growing Translational Data Science team within the Translational Medicine organization. You will be at the center of our desire to use clinical, biomarker, and single cell data to bring forward new medicines in autoimmune disease and cancer. You will leverage your creativity and analytical thinking to develop and to apply computational methods and AI/ML techniques to advance both our clinical and research programs. Your work will help us gain actionable insight from our high dimensional and multi-modal data and assess our biotherapeutics’ ability to modulate the immune repertoire. 
This is an on-site position in Cambridge, MA.
 

What you will do: 

Synthesize our data into actionable insights by supplying to the Translational teams any needed computational, statistical, machine learning or modeling capabilities needed to advance our clinical programs. Examples include: 

• Computational strategies for disease endotyping from back-translational studies to identify and rank indications for first in-human-studies as well as identify actionable targets/combinations. 

• Identification and qualification of biomarkers (e.g., selection, PD, efficacy biomarkers) and analysis of data from both our clinical and research effects 

• Assessment of treatment effects from both RNA (e.g., bulk, single cell, TCR/BCR, and spatial) and protein modalities (e.g., CITE/REAP-Seq, mIF, and high dimensional flow cytometry
   

Develop and apply computational, AI/ML methods to analyze our multi-modal data. Examples include: 

• Best practices for single cell methods including data imputation and normalization, bulk deconvolution, cell type/state analysis, cell-cell interaction/trajectory inference, reconstruction of cell type specific interactomes – cellphoneDB and spatial transcriptomic analysis and visualization 

• Pipelines for data processing and QC including visualization and integrative analysis (e.g., Nextflow, Python, shell scripts) including but not limited to quality control, alignment, variant calling, annotation, deconvolution, etc.

• Generative AI models to integrate and to analyze multi-modal molecular as well as patient clinical data 

• Interactive dashboards for data visualization and interpretation 
   

What you will bring: 

• Ph.D. in a computational, statistical, biophysics, or bioinformatics related fields

• A minimum of 5-years research (academia or industry) experience 

• First-hand experience in single cell sequencing analysis and data generation methods as well as the computing infrastructure and data management methods

• First-hand multi-parametric data mining experience for disease endotyping, target identification and biomarker analysis. For example, multivariate analysis; dimensionality reduction methods; parametric and non-parametric statistical methods; Bayesian statistics; pattern recognition or classification methods 

• Expert level fluency in statistical programming using Python, R/bioconductor or equivalents.

• Demonstrated ability to lead projects of moderate scope, mapping-out critical path, milestones and timelines, as well as manage expectations with minimal supervision.

• Demonstrated experience in deep learning and generative AI model assessment is a differentiator. 

• Curiosity to dive below the surface and proactively identify critical issues including their tactical and strategic resolutions. 

• Excellent oral and written communication 

Benefits we offer:

HiFiBiO is committed to the health and well-being of our team members and offers a variety of benefits supporting our diverse employee base. All full-time employees are eligible for our comprehensive benefits package:

• Medical, Dental, and Vision insurance (Company covers 80% of the premium cost)

• Life, AD&D, Short-term, and Long-term Disability Insurance (100% company covers) 

• Health Savings Account & Flexible Spending Account 

• Telehealth Service (100% company covers)

• Dependent Care Pre-tax Account

• Parking and Commuter Pre-tax Account

• Unlimited PTO (Paid Time Off)
  10 Paid Holidays and Sick Time (40 hours per year)

• 401(K) Plan