Director, Therapeutic Genome Editing Specificity

We are seeking a Director, Therapeutic Genome Editing with scientific leadership experience in molecular biology and genome engineering to lead our off-target characterization efforts.  Reporting to the Vice President Preclinical Research, you will leverage your industry and academic experience in the deep characterization of precision genome editing systems, including analysis and interpretation of on/off target genome editing assays. This position will play a pivotal role in enabling Metagenomi’s next-generation gene editing therapeutics by assessing the impact on genome integrity of lead therapeutic candidates. This role is based in Emeryville, California. 

• Provide strategic leadership to develop and operationalize genome-wide off-target characterization methods to support the nomination of genome editing technologies for therapeutic development
• Motivate and lead a team of talented Scientists and Research Associates
• Directly contribute to the selection and design of therapeutic candidates
• Work collaboratively with key stakeholders to deliver pivotal genome editing specificity datasets to support therapeutic candidate development
• Partner with our internal bioinformatics and data science team for high throughput method development and establishment of data analysis pipelines for off-target characterization assays
• Prepare accurate and timely data summaries and contribute to the writing of technical study reports, papers, and patent applications
• Participate in regulatory interaction meetings and provide strategic communication of off-target characterization results.

• Ph.D. in STEM-related discipline and at least eight (8) years of biopharma industry experience

• At least five (5)  years of highly relevant experience leading the development of genome editing specificity assays, including on/off target analysis

• Substantial expertise in DNA repair pathways, mechanisms of cellular transformation, and leveraging functional genomics datasets to interpret off-target assay output 

• Experience working with large datasets, including UK Biobank, Finngen, and resources, i.e., GnomAD, Exome variant server, 1000 Genomes, etc.

• Track record of successfully operationalizing genome editing characterization workflows and developing study reports supporting regulatory filings 

• Exceptional quantitative skills, including experience analyzing large experimental data in partnership with computational biologists to draw statistically significant conclusions

• Extremely organized and able to efficiently manage your time and workflows, including skillfully prioritizing both long-term projects and the day-to-day responsibilities of your team

• Direct supervisory experience leading teams of Scientists and Research Associates with a track record of recruiting, mentoring, and developing talent

• Outstanding communication, collaboration, and team leadership skills. 

California Pay Transparency Disclosure:

This position is classified as an exempt salaried position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $220,000 to $250,000.  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education.