DMPK Senior Scientist

The Position

Arrowhead Pharmaceuticals is seeking a seasoned DMPK Scientist. The Sr, Scientist will be joining a team of highly motivated and experienced chemists and biologists and contribute to the success of Arrowhead.

Responsibilities

• Develop in vitro and preclinical development DMPK strategies for nominated compounds across multiple indications and dose routes
• Manage DMPK function including both in-house resources and CROs
• Design, supervise and execute preclinical PK studies
• Provide discovery project teams with PK/PD expertise
• Oversee preclinical PK data analysis, interpretation, and reporting
• Develop IND enabling preclinical DMPK plans to meet regulatory expectations
• Execution of non-compartmental analysis using Phoenix WinNonlin software
• Assist in toxicokinetic study design, data analysis, and reporting
• Oversee metabolite identification from preclinical and clinical samples

Requirements:

• Ph.D. in Pharmacometrics, Drug Metabolism, Pharmaceutical Science, or a related discipline with at least 5 years of industry experience
• Deep expertise in all areas of DMPK, knowledge of nucleotide drugs desired
• Direct hands-on experience and strong troubleshooting skills with in vitro assays, in vivo studies, and Phoenix WinNonlin software
• Extensive experience with drug development and knowledge of regulatory processes
• Experienced with FDA regulatory guidance and communications
• A strong track record of accomplishments
• Excellent interpersonal, verbal, and written communication skills

The base salary range for this position in the selected city is $100,000 - $160,000 annually.

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