Downstream Development Engineer

Downstream Development Engineer

Dragonfly Therapeutics seeks an Associate Engineer, Downstream who brings enthusiasm, intellectual curiosity, scientific rigor and a desire to help drive novel biologics programs. The candidate must be independent, goal-oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic, and innovative individuals with a deep scientific interest in drug development, who thrive in a fast-paced, entrepreneurial environment.

Responsibilities:

• Develop and execute robust, scalable downstream processes for Dragonfly’s novel multi-specific antibody and cytokine platforms ranging from purification, filtration, and analytical characterization
• Design and improve processes related to recovery, scalability and purity, prepare technical reports, SOPs, internal and external presentations
• Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding
• Make informed decisions based on data analysis workup through excel or other statistical analysis software such as JMP
• Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks
• Effectively maintain good communication and collaborate with cross-functional colleagues and external partners for successful execution/completion of projects
• Prepare reagents, buffers, and equipment as needed to support experiments
• Additional duties and responsibilities as required

Qualifications:

• BS or MS degree in Chemical Engineering, Biochemical Engineering, Biochemistry or equivalent related fields with 3+ years relevant industrial experience required
• Strong hands-on experience in protein purification techniques such as filtration, chromatography, TFF, UF/DF, AKTA, UNICORN and HPLC systems. Experience with different modes of chromatography is desirable
• Understanding of GxP activities such as reviewing GMP batch records, tech transfer reports, and campaign summary reports is desirable
• Experience with operating and programming high-throughput liquid handling platforms (e.g. TECAN, Hamilton, etc) is desirable
• Knowledge and skills in biochemical characterization of proteins including analytical and biophysical techniques
• The candidate should be self-motivated, accountable, inquisitive, and have excellent organization and communication skills