Head, General Manager, US Commercial Markets

POSITION SUMMARY

As Amylyx Pharmaceuticals continues to scale, there is a need for a General Manager, US Commercial Markets, reporting to our Chief Commercial Officer.  This newly established role will lead the US commercial business and have accountability for US in-market performance for Relyvrio and subsequent products in the pipeline.

In this role you will be responsible for the development, oversight and execution of an integrated US commercial strategy which reflects our responsibility to foster access to treatment to people living with ALS and our responsibility to optimize our commercial capabilities and continued growth of top and bottom line results.   Direct reports include Head, US Commercial Development; Head, US Marketing; and Head, US Market Access and Patient Services

As a member of the global Commercial leadership team, the US General Manager will work in close collaboration with the Heads of Global Market Access, Global Marketing, Global Sales Training, Global Commercial Operations, Global Medical Affairs, and other executive leaders to align US commercial strategies with company objectives, nurture a culture of trust, respect and open communication,  and ensure cross-functional alignment and collaborative problem-solving.  The Head, US GM will also work in close collaboration with the Heads of International Markets – EMEA and International Markets – APAC and LatAm and Head, GM-Canada to identify opportunities for knowledge sharing, to identify opportunities for increased cross-functional/cross region effectiveness.

Exceptional leadership building and inspiring a diverse and high performing commercial team is essential. The ideal candidate will have a track record of prior experience as the top commercial leader launching rare disease products in the US.

RESPONSIBILITIES

• Provide leadership, direction, and development to the US Commercial organization, establishing the vision, objectives, and strategic plan for customer-facing teams. Provide top level leadership and accountability for US Relyvrio patient and revenue goals. This entails exceptional leadership to drive alignment and results across US Sales, Marketing, Market Access, Patient Services (ACT) and Operational teams.
• Fosters the Amylyx values, culture and ways of working and ensures they are embedded across the  US Commercial organization. 
• Establish appropriate sales targets and objectives, partnering with Finance and Commercial Ops on revenue projections and reporting. Partner with Commercial Operations to ensure optimal business planning. Provide oversight of field targeting, call planning/alignments, size and structure, and incentive compensation.
• Ensure establishment of critical KPIs in each commercial functional group.  Proactively monitor metrics to identify trends and translation of trends into adjustment in strategies and tactics, share key findings having a cross-functional implication for course adjustment and alignment.   
• Establish a close and effective collaboration with Medical Affairs to ensure field coordination and apply compliant and quality requirements to all initiatives.
• Collaborate seamlessly with Global Marketing, Global Patient & Professional Advocacy and Global Market Access teams to ensure alignment of and consistency with global standards.
• Work in partnership with Legal and Compliance, Regulatory, and other internal stakeholders to ensure tactics and operations are developed and executed in compliance with legal, regulatory, and financial guidelines.
• In partnership with Commercial Operations, contribute to the continued evolution of sales force systems, data, training programs, performance metrics
• Attract, mentor, and develop top commercial talent, nurturing a high-performing team focused on achieving ambitious goals and driving professional growth

REQUIREMENTS

• Bachelor’s Degree required. An advanced degree in Business, MBA or similar is preferred.
• Minimum 20 years’ experience in progressively more senior commercial leadership in the biotechnology and pharmaceutical industry including working in a matrix organization, management of a US P&L and leadership of customer facing teams including sales and market access.  
• Proven track record of success in driving sales and marketing strategies within the US pharmaceutical market.
• Demonstrated ability to build cross-functional teams and recruit, develop, and retain top talent.
• Prior experience leading in a matrix environment across sales, marketing, market access, patient services/advocacy, and medical affairs to deliver results.
• Prior product launch experience is a must; rare disease and Neurology experience preferred. Strong preference for experience in a global organization, helping to drive the evolution of Commercial structure as pipeline expands.
• Solid understanding of market access and how to integrate access strategies across the US to achieve positive results.
• Understand the importance and impact of external key stakeholder relationships including KOL, HCP, Payers, and provide oversight of key strategies needed to ensure patient access.
• Demonstrated ability and desire to build a culture of cross-functional collaboration and communication, building a mindset of “if we do what’s right for patients, the profits will follow”.
• Operates with professionalism and sensitivity to working with people, internally and externally, from a broad range of cultures and diverse backgrounds.
• Must be confident and inclusive, have well-honed presentation skills and the ability to collaboratively influence peers and executive leadership. Demonstrated ability to present at all levels including board of directors.
• Ability to operate effectively in a rapidly growing organization; comfortable with ambiguity and demonstrates exceptional leadership skills by confidently guiding the team through uncertain situations, maintaining a positive outlook, and fostering a collaborative and resilient atmosphere.
• Ability to travel at least 50%.

LOCATION

The ideal location is Cambridge, Massachusetts – candidates outside Massachusetts must be willing to travel to Cambridge on a regular basis in addition to US field travel as needed.