Principal Scientist, Discovery Genetics

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, neurology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

We seek a talented computational researcher to coordinate and lead target discovery efforts for neurological diseases using large-scale human genetic data. This role will sit within Informatics & Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development within BMS research.

A key focus will be identification and prioritization of drug target candidates with strong causal human biology that are aligned with company strategy for neurological diseases. This will involve application of innovative statistical genetics methods that combine human genetic data with functional and clinical data (e.g., GWAS, fine-mapping, colocalization, Mendelian Randomization, rare variant associations tests, and polygenic modeling methods) to build and inform therapeutic hypotheses, including directionality, efficacy, safety, and indication selection. It will also include synthesizing and communicating key findings at cross-functional target discovery meetings.

This position offers an exciting opportunity to impact human health through innovative human genomics research, and will enable discovery groups within BMS research to launch novel programs based on causal human biology. It is also an opportunity to work closely with the broader scientific community through pre-competitive collaborations (e.g. FinnGen, UK Biobank, UK Genes & Health, Alliance for Genomic Discovery), and to publish and present industry-leading work in this area.

Responsibilities will include, but are not limited to, the following:

• Design and perform cross-biobank analyses focused on identifying human genetic risk factors for neurological diseases (e.g. GWAS meta-analysis, rare variant burden tests)
• Design and perform integrative analyses to infer causal mechanisms driving disease using human genetics and other data types (e.g. Mendelian randomization with proteomics)
• Leverage disease specific datasets that are multi-modal and derived from consortia such as AMP AD, AMP PD, Answer ALS.
• Coordinate with stakeholders across research to nominate, evaluate, and advance novel drug targets
• Communicate findings and recommend follow up actions in multiple settings (including 1:1, seminars, project meetings, and external publications)

Basic Qualifications:

Bachelor's Degree with 8+ years of academic / industry experience

Or

Master's Degree with 6+ years of academic / industry experience

Or

PhD with 4+ years of academic / industry experience

Perferred Qualifications:

• PhD in statistical genetics, neurogenetics, or a related computational/quantitative discipline field with 4+ or more years of relevant postdoctoral research and/or industry experience preferred
• Experience applying genetics to drug discovery or other healthcare-related applications
• Deep scientific expertise in application of statistical genetic methods for causal inference
• Advanced hands-on knowledge of at least one high-level programming language such as R or Python
• Familiarity with functional genomics preferred
• Demonstrated ability to advance multi-disciplinary team projects required

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as "Transforming patients' lives through science™ ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.