R&D Scientist

Job Location: 301 Binney Street, Suite 401, Cambridge, MA 02142 (Telecommuting is available up to one day per week)

Approximately 10% domestic and approximately 10% international travel required.

This position qualifies for Generation Bio Co.’s employee referral incentive program.

The R&D Scientists will be responsible for the following duties:

1. Lead, design, and execute laboratory experiments to develop the manufacturing process for pharmaceutical substances used in gene therapy treatments;
2. Perform in-house experiments and supervise efforts related to the purification process development;
3. Perform experiments and collaborate efforts related to the development of process steps including cell lysis, enzyme-based synthesis of DNA drugs, chemical precipitation, depth filtration, tangential flow filtration, sterile filtration, viral filtration, and column chromatography;
4. Perform testing and analysis of process intermediates and final drug substance;
5. Lead tech transfer of small-scale process(es) to the MST (Manufacturing science and technology) and GMP groups for large scale manufacturing at contract manufacturing organization (CMO);
6. Provide technical resources for recent technologies in drug development;
7. Write and review protocols, reports, and manufacturing batch records; and
8. Prepare, analyze, and present data to cross functional teams.

Job Requirements:

Employer requires a Master’s degree in Pharmaceutical Sciences, Biotechnology, Bioengineering, or closely related field and at least two (2) years of work experience as a Research Scientist (or related occupation) performing downstream process development in a pharmaceutical manufacturing or industrial environment.

In addition, the employer requires the following:

1. Demonstrated ability testing and analyzing process intermediate and final drug substance samples gained through two (2) years of work experience;
2. Demonstrated ability designing, executing, and troubleshooting experiments to develop downstream processes for the purification of drugs gained through two (2) years of work experience;
3. Demonstrated ability authoring and executing protocols, interpretating data, and generating final reports gained through two (2) years of work experience; and
4. Demonstrated ability optimizing scalable purification processes and manufacturing activities in a GMP environment gained through one (1) year of work experience.

All years of experience may be gained concurrently.