Research Associate II, Oligonucleotide Therapeutics (CONTRACT)

What’s happening at Entrada Therapeutics? Our mission is to transform the treatment of devastating diseases and improve patients’ quality of life using intracellular biologics. Leveraging our proprietary Endosomal Escape Vehicle (EEV)TM platform, we are creating and advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently target and engage underlying drivers of diseases.

Our novel approach to drug design and delivery addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the field of intracellular biologics.

We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease and are excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be a versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all aspects of ocular programs, supporting efforts for testing EEV, antisense oligonucleotides, small interfering ribonucleic acids and gene editing in vitro and in vivo. You should be ready to support our team of drug discovery scientists as we evaluate all the gene targeting modalities and carry out analytical assays for functional validation both in vitro and in vivo.

The opportunity:

In this role you will have the opportunity to be involved in a lot of different aspects of our discovery biology work for the ocular programs, e.g. processing and analyzing samples from in vitro and in vivo studies will be just one of your areas of work. You’ll be expected to work through techniques like DNA/RNA/protein extraction, RT-PCR, RT-qPCR, ELISA, western blot, tissue embedding, sectioning and immunochemistry or immunofluorescence staining. You’ll also have the opportunity to maintain and culture cell lines or tissue explant for in vitro or ex vivo studies, developing and executing cell-based or ex-vivo assays for validating biological activity of oligonucleotide therapeutics. Lastly, you’ll have the opportunity to prepare SOPs and other reports and publications.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

• Humanity- We genuinely care about patients and about one another
• Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients
• Creativity- We are creative problem solvers
• Collaboration- We are more than the sum of our parts
• Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• BS with 2-4 years or MS with 1-2 years of relevant experience
• Hands-on biochemistry experience with PCR, RT-PCR, qPCR, ELISA, Western blotting, fluorescence microscopy and tissue processing is a plus
• Ability to collaborate with interdisciplinary team with strong communication skills
• Desire to work in an innovative and collaborative environment pursuing high reward science

The perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.