Research Associate, Platform Biology

Arvinas is a clinical-stage biotechnology company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being co-developed and commercialized by Arvinas and Pfizer as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 400 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say. For more information, please visit www.arvinas.com.

Position Summary 

This key position in our functional area support team (FAST) within the Platform Biology group will support the discovery and characterization of PROTACs (Proteolysis-targeting chimeras) and related molecules for Arvinas Research programs. This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members to deliver quality data in support of early drug discovery efforts.

This position will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Execute compound profiling assays using cell-based (reporter assays, high-content screening, etc.) and biochemical (TR-FRET, Alpha-Screen, etc.) formats to support efforts in developing structure-activity relationships that guide lead identification, optimization, and off-target liabilities for targeted protein degraders.
• Develop cell-based and biochemical assays to support discovery and optimization of targeted protein degraders.
• Utilize automated liquid handling systems and screening platforms to acquire data with the goal of optimizing screening throughput and quality.
• Working with senior group members and project teams, optimize assays and analyze data for storage in the corporate database and presentation at project meetings.

Qualifications

• Proficiency in aseptic tissue culture techniques and mammalian cell tissue culture is preferred.
• Experience in executing cell based and/or biochemical assays/screens in an industrial or academic core facility environment is highly desirable.
• Experience with multiple assay formats, such as luminescence, ELISA, TR-FRET, etc. is highly desirable.
• Excellent data analysis and recording skills as well as oral and written communication skills are required.
• Innovative, motivated, researcher with strong problem solving and communication skills.
• Demonstrable skill as key team member, building productive relationships with internal stakeholders, ability to understand complex scientific concepts.

Education

• BS in Biology, Biochemistry or a relevant field of study; relevant laboratory experience is highly desired.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity Employer