Scientist 1/2, Protein Engineering

Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.

We are seeking a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. The current role is for a Scientist to advance our ongoing efforts to engineer highly active and specific CRISPR enzymes.  The candidate should have a passion for building the CRISPR systems that advance our therapeutic programs. The role will work collaboratively across interdisciplinary teams, including  disease experts and computational biologists. The candidate should bring experience in protein engineering and a passion for creating tools to meet the challenge of this new frontier in genetic medicine. 

The candidate will have numerous opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a leadership role of increasing responsibilities and the ability to publish highly impactful work in peer reviewed journals. 

• Design, screen, and characterize engineered CRISPR molecules to improve activity and specificity
• Develop key new functionalities for our CRISPR-CasX platform
• Design and execute molecular biology and cloning workflows for generation of libraries of protein variants
• Design and execute pooled screening methods to select for molecules with desired attributes
• Compare and assess protein variants to produce sequence-function insights to guide engineering efforts
• Collaborate with NGS and Bioinformatics teams to build robust pipelines 
• Effectively collaborate with a fully integrated team to facilitate execution on projects within established timelines.
• Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science

• A PhD in Bioengineering, Biochemistry, Biophysics, Synthetic Biology, Genetics or related discipline.
• At least 2 years of experience working in an academic or industry lab, with a proven track record of expertise in molecular biology, protein engineering, and pooled screening.
• Experience with protein engineering, including deep mutational scanning, directed evolution, and rational design approaches. 
• Experience with pooled screening and selections.
• Experience in designing reporter systems, screening in human cells, and readout by FACS and NGS.
• Demonstrated quantitative and scientific thinker as evidenced by a strong publication record.
• Ability to work both independently and collaboratively in a fast-paced, interdisciplinary research team.

• Experience in engineering CRISPR-Cas systems.
• Familiarity with CRISPR therapeutic approaches.
• Experience with functional genomics or next-generation sequencing approaches.
• Experience with computational tools for analysis of biological data.
• Working knowledge of statistics to enable the design and analysis of pooled screens with >10K library members.
• Experience with Rosetta or other packages for computational protein design.

Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Visit us at www.scribetx.com.  

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.