Scientist

Overview

Axle is a bioscience and

information technology company that offers advancements in

translational research, biomedical informatics, and data

science applications to research centers and healthcare

organizations nationally and abroad. With experts in

biomedical science, software engineering, and program

management, we focus on developing and applying research

tools and techniques to empower decision-making and

accelerate research discoveries. We work with some of the

top research organizations and facilities in the country

including multiple institutes at the National Institutes of

Health (NIH).

Axle

is seeking a

Scientist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD.

Benefits We Offer:

• 100%

  Medical, Dental & Vision Coverage for Employees

• Paid Time Off and Paid Holidays
• 401K match up to 5%
• Educational

  Benefits for Career Growth

• Employee Referral Bonus
• Flexible

  Spending Accounts:

  • Healthcare (FSA)
  • Parking

    Reimbursement Account (PRK)

  • Dependent

    Care Assistant Program (DCAP)

  • Transportation

    Reimbursement Account (TRN)

Overall Position Summary and Objectives

Under this task order, the contractor will independently provide support services to satisfy the overall operational objectives of the National Center for Advancing Translational Sciences, Therapeutics Development Branch (TDB). The primary objective is to provide services and deliverables through the performance of support services.

Deliverables:

• Upon request, the contractor shall provide documentation evidence of any and/or all work products, including, but not limited to, the following tasks (Quarterly):

1. Work on products and documents related to scaling up and synthesizing APIs and intermediates; design and develop scalable synthetic routes; optimize synthetic steps; isolate and identify impurities.
2. Work on products and documents related to producing research reports; generate reports to support technology transfer to CROs; conduct and write literature reviews; search chemical databases for journal articles, patents and related technologies; publish and present relevant projects.
3. Work products and documents related to collaboration with the technology transfer office and external patent offices to provide the necessary information for filing patents in selected programs.

• Clean Equipment - Weekly
• Meet with lab members to present updates - Monthly

Work Details:

• Provides laboratory experience needed to assist in performing various chemical experiments and procedures.
• Perform synthetic route scouting 1
• Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models. 2
• Perform chemical and biochemical reactions and appropriate analytical analyses.
• Perform analytical validation and testing of compositions.
• Utilizes and operates various complex laboratory machines and equipment.
• Perform general maintenance and upkeep of equipment and instrumentation.
• Troubleshoot and provide routine maintenance of the instruments and equipment.
• Monitor, troubleshoot and initiate or take corrective action to maintain instrument function and quality.
• Identify the cause of common problems and mistakes and make necessary repairs.
• Documents and analyzes results, produces detailed summaries and reports.
• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals.
• Maintain up-to-date electronic laboratory notebook detailing all experiments. 3
• Collect and review data; analyze and interpret data and results.
• Produce research reports and communicate results.
• Search chemical databases for journal articles, patents and related technologies. 5
• Gather, analyze and interpret data; prepare summaries and reports. 4
• Analyzes organic and inorganic compounds to determine chemical and physical properties, composition, structure, relationships between compounds, and reactions.
• Formulate chemistry plans for the development of soluble, potent, selective small molecule probes of biological function.
• Analyze samples using validated analytical methods for ongoing studies.
• Perform the total syntheses of target compounds.
• Manage bulk-synthesis, purification and formulation efforts for advanced testing in animal models.
• Perform chemical synthesis and optimization of small molecule probes for use in biological research.
• Perform organic synthesis of key materials (e.g., reference compounds and precursors for labeling).
• Perform organic synthesis in support of the medicinal chemistry program.
• Perform solid state analysis of target compounds
• Adds heat, light, energy or a catalyst to show changes in composition.
• Purify compounds by preparative chromatography from chemists.
• Provides laboratory experience needed to perform various complex chemical experiments and procedures.
• Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models.
• Perform analytical validation and testing of compositions.
• Prepares test solutions, compounds, and reagents and maintains necessary laboratory supplies.
• Prepare reagents and maintain an active inventory of all chemicals kept in the laboratory.
• Keep an active inventory of all chemicals kept in the laboratory.
• Schedules, tracks and reports analyses of experiments and procedures.
• Perform analytical validation and testing of compositions and report results.
• Maintain computer database for various records.
• Independently provides laboratory experience needed to perform various complex chemical experiments and procedures.
• Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models.
• Develop new analytical and separation techniques for the solution of scientific questions.
• Perform analytical validation and testing of compositions.
• Designs and optimizes chemical experiments and procedures.
• Develop and document new procedures.
• Develop novel chemistry methodologies and technologies that advance the field and make recommendations.
• Collaborate with staff to evaluate and/or develop new techniques.
• Develop and present plans for novel syntheses and approaches to new compounds.
• Develop experimental procedures and research protocols.
• Develop and present plans for novel syntheses and approaches to new compounds.
• Carry out scale-up of the chemical probes of interest for additional studies.
• Trains staff on new experiments and practices, operations and maintenance of instruments and equipment, safety practices, etc.
• Maintain and perform training on scientific instrumentation and equipment.
• Work with staff on all mandatory training and competency assessments.
• Coordinate safety training (e.g., CPR and fire extinguisher use).
• Work with facilities manager on evacuation procedures and drills.

1, 2, 3, 4, 5 represents

priority rankings, where 1 is highest priority and 5 is

lowest priority of those ranked

Minimum Education

Masters

Additional Qualifications:

Certifications & Licenses

• Good Manufacturing Practice (GMP)

Field of Study

• Chemistry

Software

• Powerpoint
• MS Project
• Outlook
• Excel
• Word

Skills

• Microscopy: Confocal, Electron, Multi-Photon, Fluorescence, Super-Resolution
• Nuclear Magnetic Resonance
• Thin-layer chromatography
• X-Ray Crystallography
• Manuscript writing
• Mass Spectrometry
• Spectrophotometry
• Thermal analytical technologies
• Chromatography technologies (HPLC, UPLC, GC, IC)
• Kilo Lab or pilot plant experience

Disclaimer:The

above description is meant to illustrate the general

nature of work and level of effort being performed

by individuals assigned to this position or job

description. This is not restricted as a complete

list of all skills, responsibilities, duties, and/or

assignments required. Individuals may be required to

perform duties outside of their position, job

description or responsibilities as needed.

The diversity of

Axle's employees is a tremendous asset. We are firmly

committed to providing equal opportunity in all aspects of

employment and will not tolerate any illegal discrimination

or harassment based on age, race, gender, religion, national

origin, disability, marital status, covered veteran status,

sexual orientation, status with respect to public

assistance, and other characteristics protected under state,

federal, or local law and to deter those who aid, abet, or

induce discrimination or coerce others to discriminate.

Accessibility: If

you need an accommodation as part of the employment process

please contact: mailto:[email protected]" target=" _blank" rel="

noopener" data-mce-href="

mailto:[email protected]">[email protected]