Scientist Gene Editing (CONTRACT)

What's happening at Entrada Therapeutics? Our mission is to transform the treatment of devastating diseases by establishing a new class of medicines to engage intracellular targets that have long been considered inaccessible and undruggable.

Our Endosomal Escape Vehicle (EEV™)-therapeutics represent a fundamental advancement in the field of intracellular therapeutics. They are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through our EEV platform, we are building a diverse pipeline of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, immunological, ocular and metabolic diseases, among others. 

Our lead oligonucleotide programs include ENTR-601-44 and ENTR-601-45 for the potential treatment of people living with Duchenne who are exon 44 and 45 skipping amenable, respectively, as well as our partnered candidate ENTR-701 targeting myotonic dystrophy type 1 (DM1). 

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families. 

 The Perfect Addition to Our Team 

You should be a versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all aspects of oligonucleotides, supporting efforts for antisense oligonucleotides, small interfering ribonucleic acids and gene editing platforms. You should be ready to support our team of drug discovery scientists as we design, prepare and characterize oligonucleotide constructs and carry out analytical assays for functional validation both in vitro and in vivo.The Opportunity 

In this role you will have the opportunity to be involved in a lot of different aspects of our gene editing work, including processing and analyzing samples, as well as in vitro and in vivo studies will be just one of your areas of work. You’ll be expected to work through molecular techniques like RNA/protein extraction, RT-PCR, ELISA, flow cytometry, and next-generation sequencing. You’ll also have the opportunity to maintain and culture cell lines for in vitro studies, as well as developing and executing cell-based assays for validating biological activity of novel gene-editing medicines. Lastly, you’ll have the opportunity to prepare SOPs and other reports and publications. 

• You’ll be expected to work through molecular techniques like RNA/protein extraction, RT-PCR, ELISA, flow cytometry, and next-generation sequencing.
• Maintain and culture cell lines for in vitro studies, as well as developing and executing cell-based assays for validating biological activity of novel gene-editing medicines.
• Lastly, you’ll have the opportunity to prepare SOPs and other reports and publications. 

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• PhD in Cell and Molecular Biology, Biochemistry, Immunology or similar scientific disciplines with 0-2 years of industry/post-doctoral experience for a Scientist I and 2-4 years of industry/post-doctoral experience for a Scientist II. 
• Hand-on experience in molecular and biochemistry techniques, including but not limited to PCR/qPCR, western blot, multi-color flow cytometry, and gene editing using CRISPR/Cas9.
• Experience in mammalian cell and tissue culturing is required.
• Experience in primary immune cell culture, including myeloid cells and lymphocytes, and immunological assays using flow cytometry is required. 
• Experience in gene editing and next-generation sequencing is highly desirable
• Familiarity of graphic and statistical software and Microsoft Office
• Demonstrate independence in study planning and execution, analyze and present research data to key stakeholders to drive progress and decision.
• Ability to collaborate with interdisciplinary teams with strong communication skills. Desire to work in an innovative, fast-pace, and collaborative environment pursuing high reward science

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.