Scientist Hematology, Discovery Research

SUMMARY: 

Generation Bio is seeking an energetic and highly motivated Scientist to join the hematopoietic stem cells (HSC) team within the Discovery Research group. The position will play a key role in development and evaluation of our cell targeted lipid nanoparticle (ctLNP) delivery platform by developing and executing in vitro and in vivo assays aimed at evaluating ctLNPs interacting with HSCs.  The ideal candidate will have a strong background in cell-based assays (such as, but not limited to HSC colony forming assay, ELISAs and flow cytometry) and experience in HSC engraftment in immunodeficient mice model, isolating and maintaining HSCs, and other primary immune cells. Experience in ex vivo and in vivo gene editing in HSC and primary cells is preferred.  Responsibilities will also include cross-functional research to enable early program development for indications in target cell types.

RESPONSIBILITIES:

• Contribute to the design, optimization and execution of assays to assess ctLNP interactions with HSC and primary immune cells.
• Work with Discovery Organization to evaluate novel ctLNPs and target biology for new platform technologies.
• Support discovery effort for in vivo cell targeted delivery.
• Summarize work in written reports and oral presentations.

QUALIFICATIONS:

• Experience in the fields of hematology or cell biology (or related)
• Ph.D. in hematology or biochemistry or molecular biology or related field of study with minimum of 3 years of industry experience, including strong publication records.
• Demonstrated leadership and hands on experience in primary HSC based assay development and execution.
• Experience isolating and culturing HSCs and primary immune cells from human and/or mice required.
• Knowledge of flow cytometry and simple multi-color panel design required.
• Experience with CRISPR/Cas-based genome editing desired.
• Experience with QPCR, western blot techniques, ELISAs, etc a plus.
• Ability to work cross functionally in a dynamic matrixed environment.
• Ability to multi-task to support multiple projects across platform discovery organization.
• Organized, excellent communication skills, collaborative mindset.

POSITION: Full-Time, Exempt