Scientist I

The Scientist I plans and conducts experiments under the direction of a Scientist II for in vitro studies to advance our portfolio of genetic therapies spanning Gene Therapy, RNA, and Gene Editing treating neuromuscular and CNS-related diseases. This role supports in vitro disease modeling efforts and develops cutting-edge technology platforms for therapeutic applications. The Scientist I works as part of the team in our Genetic Engineering Innovation Center as well as with the broader research teams in Ohio and Massachusetts. Reporting structures may shift as the North Carolina site grows.

Primary Responsibilities Include:

• Maintain mammalian cell cultures that support in vitro disease modeling platforms.
• Assist in developing 2D and 3D in vitro disease modeling platforms to test the Sarepta portfolio of therapeutic modalities.
• Plan and conduct experiments evaluating novel therapeutic interventions and assist in identification of lead therapeutic strategy; may provide training and guidance to junior team members.
• Participate as part of a team in a laboratory setting; plan, design and work as a technical lead to improve process efficiency and ensure a functional and safe working environment.
• Research and evaluate new methods and technologies for continual process improvement in support of discovery research efforts.
• Follow scientific direction to execute and meet project timelines and deliverables for assessing lead therapeutic candidates.
• Prepare and review protocols, laboratory documentation, technical reports, and standard operation procedures (SOPs). 
• Record and document experimental data appropriately; interpret data, document study results and present data to diverse functional groups.
• Responsible for troubleshooting equipment as well as identifying and characterizing necessary critical materials; ensure that scientific and technical challenges are resolved in a timely manner.
• Performs other related duties as assigned.

Desired Education and Skills:

• Advanced degree in a scientific discipline required, Ph.D. preferred, with at least one year of experience in molecular biology research, neuromuscular disease research, and/or gene therapy research or development.
• Knowledge and hands-on experience with 2D and 3D in vitro musculoskeletal and/or cardiac disease models is highly desirable.
• Experience with iPSC culture, reprogramming and directed differentiation is highly desirable.
• Strong understanding of gene editing technologies and experience with mammalian cell line engineering and development.
• Experience with molecular and cellular biology techniques including transfection, viral transduction, CRIPSR-based gene editing, digital PCR, western blot, flow cytometry, cryosectioning and IF staining.
• Knowledge and experience with gene therapy vector design and next generation sequencing.
• Technically proficient with strong critical thinking and analytical skills; ability to identify and implement scientific solutions to practical problems.
• Analyzes and communicates experimental results to colleagues and management demonstrating effective written and verbal communication skills.
• Demonstrated time management skills, ability to work on multiple projects simultaneously with the flexibility to accommodate changing priorities and deadlines; ability to work independently as well as within multi-disciplinary project teams.
• Proficiency with Microsoft Office Applications (Word, Excel, Outlook), gene editing software, and other functional systems.
• Desire to work in a dynamic, fast-paced, team environment and to make a difference in the lives of people through our innovative therapeutics.

#LI-Onsite

This position requires work on site at one of Sarepta’s facilities in the United States.

The targeted salary range for this position is $91,200 - $114,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.