Scientist I, Protein Sciences

The Position:

At Maze Therapeutics, we’re focused on translating cutting-edge genetic insights into lifesaving medicines. Our scientists decode the genetic drivers of disease and leverage our findings to develop innovative therapeutics. In this role, you’ll play a crucial part by purifying and characterizing protein targets, and in partnership with Drug Discovery’s Medicinal and Computational Chemistry teams you will design and optimize novel small-molecule therapeutics.  Collaborating with our Translational Genomics team, you’ll also delve into the biophysical mechanisms of protein-altering human genetic variants. 

Your Impact:

• Design and execute protein expression and purification experiments to enable drug discovery initiatives and assess new targets.
• Investigate ligand-protein interactions using an array of biophysical and biochemical methods.
• Explore molecular mechanisms of protein-altering genetic variants and ligands using structural and biophysical methods.
• Interpret and present findings, contributing insights in cross-functional research team meetings.
• Contribute to reports and scientific publication writing.

Skills and Qualifications:

• PhD in Biochemistry/Biophysics/Structural Biology with relevant experience or BS/MS with equivalent industry background.
• Demonstrated proficiency with multiple protein expression systems (bacterial, insect, mammalian).
• Technically adept in protein characterization with various biochemical and biophysical methods (DSF, SPR, MST, MS).
• Working knowledge of structural biology methods and computational structural analysis tools (PyMOL, ChimeraX, AF2).
• Experience with multi-subunit protein complexes and membrane proteins is a plus.
• Ability collaboratively and work with cross-functional teams.

About Maze Therapeutics

Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases, such as chronic kidney disease, and seeks to focus expertise and resources towards underserved communities. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass Platform™, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass Platform™, Maze is building a broad portfolio of wholly owned and partnered programs. Its two lead programs are focused in Chronic Kidney Disease (CKD), a condition that impacts an estimated 37m individuals. The first program in CKD addresses a genetic subset of the common disease that has a disproportionate impact on the Black Community. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.  

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. 

Stand True – Our integrity is foundational; it guides us no matter the obstacle. 

The expected annual salary range for the Scientist I, Protein Science position for employees located in the San Francisco Bay Area is $117,000 - $143,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future. Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.