Scientist II

Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered.

At AskBio, we've built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson's disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.

We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain.

Our vision: Pioneering science to create transformative molecular medicines.

Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.

Our principles:

• Advance innovative science by pushing boundaries.
• Bring transformative therapeutics to patients in need.
• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
• Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.

Responsibilities and Accountabilities

• Serve as a SME and/or lead scientist, lead and manage the internal and external bioanalysis and bioassay assay design, development, troubleshooting, transferring, and sample testing and reporting to support preclinical and clinical gene therapy program development.
• Independently develop, optimize, and troubleshoot cell-based assays as well as other plate-based assays using variety of platforms including but not limited to Simple Western, colorimetric/luminescent/fluorescent ELISA, MSD, enzyme activity assay, and high-content imaging in support of potency assay development for gene therapy programs.
• Prepare/scientific review of analytical data and methods, protocols, and reports generated by internal and external laboratories.
• Participate and present in departmental and cross-functional project team meetings.
• Author and review relevant sections of regulatory submissions support the IND/CTA and BLA/MAA submissions.
• Stay current with the latest bioanalytical and bioassay methods and technologies, current regulatory regulation and guidance, and industry's best practices.

Qualifications

• Ph.D. in Biology, Biochemistry, molecular biology, Cell Biology, or a related field with minimum 3+ years of relevant experience and a strong publication record in peer reviewed journals or Master with 6+ years of directly related industry experience.
• In depth knowledge and extensive research experience in cardiomyopathy or neuromyopathy are desirable
• Deep understanding and extensive research experience in MoA, potency, and cellular signaling pathway.
• Experience and expertise in virus-related research including cell culture, virus transduction, stable cell line development, and characterization.
• Highly experienced in experiment designing, executing, and troubleshooting for cell-based assay, ELISA, MSD, cell-based assay, FACS, or other novel platforms.
• A strong self-starter and team player, independent strategic thinker, with a strong attention to details and excellent problem solving and complexity reduction skills.
• Ability to achieve objectives/timelines through collaborative efforts with coworkers, and managers.
• Excellent communication, interpersonal, organizational, and multi-tasking skills.

Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job-related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) 561-6210 or sending us an email at [email protected].

Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency.