Scientist II, Analytical Development- Oligonucleotides

Job Description

Biogen is seeking a qualified and motivated candidate to fill a Scientist II position within its Oligonucleotides Analytical Development organization. This individual will work with other scientists to develop state-of-the-art analytical methods for the release and characterization of oligonucleotide-based products in the Biogen portfolio from pre-clinical through commercialization. This position is ideally suited for someone with a background and broad knowledge in oligonucleotide therapeutics and the methods used to analyze them. Particularly, prior experience with liquid chromatography and mass spectrometry are preferred.

The successful candidate will design, execute, and document analytical method development and qualification experiments, work with other team members and the team manager to devise phase-appropriate analytical control strategies for the different oligonucleotide products, and collaborate with key stakeholders from different parts of the technical CMC organization including process development, manufacturing sciences, quality control, regulatory CMC, and asset leaders.

This is an on-site role based at our Headquarters in Cambridge, MA. 

Responsibilities include (but are not limited to):

• Develop, optimize, and qualify LC-MS based method for the characterization of oligonucleotide products.
• With the help of peers and the manager, design experiments, execute them, analyze the data, and author reports.
• Maintain analytical instruments, troubleshoot them, and coordinate their preventative maintenance or service request with the appropriate teams.
• Practice tidiness and cleanliness in the laboratories and don personal protective equipment to ensure a safe and compliant working environment.
• Develop control strategies and propose specifications for drug substances and drug products.
• Actively engage with CMC teams as the analytical development program representative (ADPR) to advance the Biogen oligonucleotides programs. Contribute to deliverables and participate in cross-functional technical review and troubleshooting.
• Propose and advocate for project timelines; be the primary point of contact for analytical control strategies, and method transfer to QC and external partners.
• Author relevant sections of regulatory filing documents and formulate responses to the regulators’ questions.
• Champion and lead innovation in new technologies, data analysis, and machine learning applicable to analytical development.
• Demonstrate impact through scientific presentations at internal (group meetings and townhalls) and external (conferences) meetings. Get involved in industry-wide consortia and working groups to shape the future of oligonucleotide therapeutics development.

Qualifications

• Ph.D. in Chemistry, Materials Science, Chemical Engineering, or related field with 0 - 4 years of relevant industry experience (Early summer graduates may be considered). Equivalent experience equals a M.S degree and 6+ years of experience or Bachelor's degree and 8+ years of experience. 
• Hands-on experience in analytical method development.
• Good knowledge of oligonucleotides therapeutic development
• Experience in LC-MS based techniques. Broad knowledge in the different types of chromatography methods and different types of mass spectrometry instruments.
• Strong problem-solving and troubleshooting skills, strong capabilities in experimental design and execution, as well ability to work independently are essential.
• Strong verbal and written communication skills, strong interpersonal skills and the ability to serve as a team member/leader in an environment where individual initiative, collaboration and accountability are valued.
• Proven skills and ability to work collaboratively with both internal and external partners.

Additional Information

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.