Scientist II, Invitro Pharmacology

What's happening at Entrada Therapeutics? Our mission is to transform the treatment of devastating diseases by establishing a new class of medicines to engage intracellular targets that have long been considered inaccessible and undruggable.

Our Endosomal Escape Vehicle (EEV™)-therapeutics represent a fundamental advancement in the field of intracellular therapeutics. They are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through our EEV platform, we are building a diverse pipeline of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, immunological, ocular and metabolic diseases, among others. 

Our lead oligonucleotide programs include ENTR-601-44 and ENTR-601-45 for the potential treatment of people living with Duchenne who are exon 44 and 45 skipping amenable, respectively, as well as our partnered candidate ENTR-701 targeting myotonic dystrophy type 1 (DM1). 

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families. 

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all aspects of our in vitro pharmacology efforts, leading the company’s preclinical studies to advance lead programs in a variety of diseases including for immunology targets. You’ll excel in a matrixed environment and enjoy wearing many hats as is customary in agile startups. You should have a strong foundational knowledge of immunology and a willingness to share your expertise throughout the company. We are excited for you to provide insights on new drug targets, therapeutic hypotheses, and to guide drug discovery efforts and translation into the clinic. We hope you enjoy contributing to scientific publications and regulatory submissions, you will get to do some of that too. You should be excited to mentor and train our more junior scientists, our team is all about learning and growing with the company!

The opportunity:

As part of the Pharmacology Group, this position comes with the opportunity to contribute broadly to advancing validated targets into the drug discovery pipeline. In this role, you will be responsible for designing and leading our in vitro preclinical studies to advance programs including target nomination, analysis, and building scientific rationales for disease selection. You will evaluate, validate, and develop disease models to investigate the efficacy of EEV-mediated delivery including in vitro techniques to drive go/no-go decisions. In this role, you won’t be siloed! You will regularly collaborate across teams and with the Discovery Group to demonstrate mechanistic proof-of-concept and contribute to selecting novel therapeutic modalities that include oligonucleotides, peptides, and antibodies.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Ph.D, with 2+ years of additional experience
• Experience in in vitro laboratory techniques (PCR, gel electrophoresis, Western blots, RNA and protein extraction, qPCR, ELISA, mammalian cell (tissue) culture, transfection and lentiviral related work experience.
• Experience with cellular readouts such as luminescence, cell viability, fluorescence, ELISA, flow cytometry, high content imaging, etc. is ideal
• Demonstrated expertise in developing immunological phenotypic assays including- phagocytosis/ efferocytosis, T-cell activation, macrophage polarization, antigen presentation, etc
• Demonstrated ability to independently troubleshoot problems requiring original thought
• Be able to solve routine to complex operation and scientific problems requiring original thinking and deductive reasoning
• Good working knowledge of Microsoft suite of Software (Word, Excel, PowerPoint);
• Excellent verbal and written communication skills
• Strong communication skill and ability to work effectively across cross functional teams
• “Hands-on” mentality in moving projects forward
• Desire to work in an innovative and collaborative environment pursuing high reward science

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location is in the vibrant and growing Seaport District, close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.