Scientist - Immunologist (Generalist)

Scientist, Immunologist (Generalist)

Novome is building genetically engineered microbial medicines (GEMMs) that perform defined activities in the human gut to treat chronic diseases. We have developed the first platform for controlled colonization of the gut with engineered therapeutic bacteria. We are focusing current research efforts on making a microbial cell therapy to treat inflammatory bowel disease (IBD).

We are seeking a talented immunologist with expertise in adaptive immunity and murine models of disease to be a critical scientific driver of our IBD preclinical program. The ideal candidate will be skilled in a variety of immunological assays and possess extensive in vivo experimental design expertise. Scientists are responsible for leading characterization of therapeutic candidates and developing the necessary in vitro cell-based assays and in vivo animal disease models for establishing efficacy of our IBD GEMMs. They will design experiments to evaluate sophisticated therapeutic strains in the most relevant conventional and ex-germ-free humanized animal models, with access to support from animal research and strain engineering teams. Scientists will work in a collaborative, transparent environment with other gut microbiota, synthetic biology, disease area and clinical experts to bring new therapeutic bacterial strains from conception to IND filing.

Responsibilities

• Drive translation of bacteria with novel engineered activities from in vitro proof-of-concept through to IND filing
• Work with scientists across different disciplines to design and set up in vitro, ex vivo, and in vivo experiments to support multiple platforms/programs, leveraging molecular assays, mammalian cell culture, and animal models of disease
• Work closely with clinical and disease area experts to envision therapeutic strategies and evaluate or troubleshoot in vivo performance
• Train an animal research team on disease model specific techniques
• Contribute to defining the possibilities and direction of immunologically-focused indications

Key Qualifications

• PhD in immunology or molecular/cell biology with an immunology focus, or equivalent industry experience
• Deep knowledge of cellular immunity required
• Proven ability to interpret complex animal data to draw conclusions about therapeutic effects on both local and systemic immune functions
• Extensive experience with in vitro immunological assays, including cell-based reporter assays, and in vivo experimental design and execution
• Experience with commensal bacteria or mucosal immunology of the GI tract is a plus
• Comfort driving independent work and flexing into areas of less experience
• Eagerness to work collaboratively on a team of experts while adapting to the fast-paced need of a startup

To apply, please use the form on the right-hand side of this page.

Novome Biotechnologies, Inc. is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.