Scientist I/Scientist II, Novel Capsid Discovery, Receptor Identification

About Voyager

We are Voyager Therapeutics, a pre-clinical stage biotech compelled by curiosity and powered by persistence. Voyagers are bold innovators who are energized in unlocking the full potential of AAV gene therapy employing our TRACERTM capsid discovery platform. Our resolve is to advance the field of AAV gene therapy, and through our innovative capsids, we are extending the reach and impact of our technology to help more patients in need.

Recognizing that we can expand on the experience, innovation, and outcomes that propel our efforts by working together, we actively seek diverse views. If you’re someone who wants to make discoveries that change the landscape of medicine for patients, we want you on our team!

Job Summary

The Novel Capsid Discovery team is generating a portfolio of designer AAV capsids with tailored properties, which could prove truly transformative for the future of gene therapy. We are looking for a talented and motivated Scientist I/Scientist II to join the Novel Capsid Discovery team in order to expand our receptor identification platform. This will involve identifying and characterizing cellular receptors utilized by Voyager’s expanding portfolio of engineered capsids in addition to applying targeted evolution screens to identify capsids with tissue/disease specific tropism.

Key Responsibilities

• Design and implement assays to identify cellular receptors of engineered capsids
• Validate and characterize identified capsid: receptor interactions through multiple assays including transduction, binding assays and the generation of stable cells lines
• Construct complex AAV libraries to perform targeted evolution screens
• Characterize the in vivo tropism of engineered capsid libraries
• Collaborate with a diverse team of wet-lab and computational scientists

Qualifications

• PhD in biology, biochemistry, biomedical engineering, or a related field
• 5+ years hands-on wet lab experience
• Expertise in cell culture and aseptic techniques
• Proficiency in cloning design and techniques
• Experience in tissue handling and DNA/RNA purification
• Experience in quantitative assays (RT-PCR, ddPCR, reporter gene assays)
• Strong collaborative, organizational, and presentation skills
• Ability to document, maintain, and share an organized account of lab work and results

Preferred qualifications

• Experience with flow cytometry and cell-sorting
• Hands-on experience with CRISPR/CRISPRa screens
• Experience with animal tissues
• Experience with AAV vectors and library generation/screening

Voyager Therapeutics requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  Voyager Therapeutics will consider reasonable accommodations as required by federal, state, and local laws.