Scientist, Neuromuscular Research

Role Summary:

The Scientist, Neuromuscular Research plays a critical role in developing new therapies for genetic disorders, with a focus on neuromuscular diseases. This role is involved in all aspects of in vitro and in vivo exploration of disease biology and in the evaluation of mechanisms of action, efficacy, pharmacodynamics, and pharmacokinetics of our therapeutic molecules. This role leads from the bench and conducts the development and implementation of patient cell and animal disease models that support ongoing projects. The person in this role brings key strategic thinking and provides core scientific leadership to cross-functional teams. As part of the Dyne research team, this individual is an innovative and collaborative team player who enjoys working in a fast-paced team setting driven by aggressive timelines. This role requires substantial commitment to the bench and is based in Waltham, MA without the possibility of being remote. Applicants must be able to relocate to the area.

Primary Responsibilities Include:

• Design, execute, and analyze in vitro and in vivo studies to profile candidates for proof of mechanism and proof of concept.
• Evaluate and validate models of rare genetic disorders.
• Utilize creativity and resources to design, evaluate, and develop new assays to answer key scientific questions to drive programs towards clinical development.
• Work effectively with other functions including Platform Development and Preclinical Development to collectively build the preclinical data package to support clinical development.
• Build high-quality presentations and effectively communicate research to senior scientific leadership and at cross-functional opportunities.
• Contribute to a culture of strong scientific curiosity and build a positive, team-oriented environment.

Education and Skills Requirements:

• PhD in molecular biology, pharmacology or related life sciences and 2+ years of hands-on post-doctoral experience or BSc/MSc with 5+ years of relevant industry experience is required.
• Experience in providing scientific and technical leadership applied to novel assay development, advancing challenging drug discovery programs, and mentoring junior colleagues.
• Strong hands-on experience working with disease models including primary cell culture and rodent models.
• Experience with established molecular techniques including qPCR, western blotting, ELISA, immunohistochemistry/immunofluorescence, fluorescence in-situ hybridization, flow cytometry, and confocal microscopy.
• Strong written and oral communication skills, organization, and multitasking, and working in a highly collaborative and cross-functional research environment.
• Proven ability to work independently and to facilitate interactions with academic labs to ensure project progression is desirable.
• Strong track record of scientific accomplishments with relevant peer-reviewed publications and presentations.

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