Scientist, Neuromuscular Research

The Scientist in Neuromuscular Research supports development of new therapies for genetic muscle diseases. This role is involved in all aspects of in vitro/in vivo muscle disease biology, evaluating efficacy, pharmacodynamics, pharmacokinetics, and mechanisms of action of our therapeutic molecules. This role leads from the bench and conducts the development and implementation of cell-based muscle disease models that support ongoing projects as well as identification and validation of new disease targets. As part of the Dyne research team, this individual is an innovative and collaborative team player and an ambitious self-starter who enjoys working in a fast-paced team setting.

• Design, execute, and analyze in vitro and in vivo studies to establish proof-of-mechanism and proof-of-concept of therapeutic candidates
• Hands-on experimental design, execution, and data analysis of efficacy studies to drive go/no go decisions
• Utilize resources to design, evaluate, and develop new assays to answer key muscle disease questions to drive programs towards clinical development
• Evaluate and validate human and animal models of neuromuscular diseases
• Contributes to the progress of therapeutic candidates from Research to Clinical Development by providing scientific and technical expertise, and by working effectively within cross-functional project teams
• Contribute to building a positive, team-oriented culture, by fostering Dyne core values

• Ph.D. in molecular biology, pharmacology or related life sciences and 2+ years of post-doctoral experience or BSc/MSc with 5+ years of relevant industry experience is required
• Experience in providing scientific and technical leadership applied to novel assay development, advancing challenging drug discovery programs, and mentoring junior colleagues is desirable
• Track record of scientific accomplishments with relevant publications and presentations
• Strong hands-on experience working with disease models including primary cell culture using molecular techniques including qPCR, ELISA, Luminex, immunohistochemistry, immunofluorescence, in-situ hybridization, Western blot, and fluorescent/confocal microscopy
• Hands-on experience with various in vivo techniques including dosing (IV, IM, IP, SC), blood/tissue collection and knowledge of various preclinical model systems
• Strong written and oral communication skills, organization, and multitasking, and working in a highly collaborative and cross-functional research environment
• Proven ability to work independently and effectively manage CROs and to facilitate interactions with academic labs to ensure project progression

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