Scientist, Nucleic Acid Design

Scribe Therapeutics is seeking a creative and driven individual to join us in our quest to develop the next generation of therapeutic molecules to address diseases of high unmet need. The current role is for an investigator with expertise in nucleic acid design and modification for delivery of mRNA and/or oligonucleotides. The successful candidate will drive the development, optimization and characterization of mRNA designs for use in LNP-delivered CRISPR therapies.

The candidate will have opportunity for professional growth in a fast-paced biotech start-up, which includes leadership roles of increasing responsibilities and the ability to publish highly impactful work in peer-reviewed journals.

Key Responsibilities:

• Design, build and optimize mRNA molecules for optimal translation of CRISPR gene-editing systems in vivo.
• Work with team on in-house production of mRNA for rapid iterative testing 
• Establish and maintain rigorous QC processes
• Ensure high quality data generation through proper assay validation and qualification
• Collaborate across pre-clinical therapeutic groups in the company and externally to drive advancement of nucleic acid drug components
• Critically evaluate experiment data and communicate scientific findings as verbal presentations and written reports
• Mentor junior team members

Scientific and Leadership expectations:

• Interface and coordinate with other teams at Scribe to accomplish common goals
• Foster a driven, fast-paced, dynamic and fun environment in which to do rigorous science

Required Skills and Background:

• PhD. in molecular biology, biomedical engineering, chemistry, chemical engineering, or related field with at least 5 years experience with nucleic acid design, experimentation or  production
• Prior experience with oligonucleotide delivery and/or LNP technologies
• Experience with IVT methods
• Demonstrated scientific productivity and drive as evidenced by a strong publication record in top tier journals
• Track record of independence and leadership
• Ability to work collaboratively in a fast-paced, interdisciplinary research team
• Excellent prioritization and organization skills

Salary will be commensurate with experience. Scribe provides an intellectually stimulating, collegial and fast-paced biomedical research environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Please contact us and include your CV or résumé.

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

About us:

Scribe is an early-stage biotech startup developing the next generation of CRISPR systems to treat the underlying cause of genetic diseases. We are a dynamic team of energetic, creative, world-class experts who are looking for like-minded passionate colleagues to enable the future of genetic medicine.