Scientist / Sr Scientist, In Vitro Pharmacology

As a Scientist / Sr Scientist In Vitro Pharmacology in the Institute of Medicine (IOM) at Altos Labs, you will join a dynamic team in a unique environment where leading research labs work side by side with industry scientists. You will be responsible for developing biophysical, biochemical and cell-based assays. Your work will support our efforts to understand the deep mechanistic biology of rejuvenation/aging in support of target validation. Additionally, you will contribute to our drug discovery campaigns through the selection of drug candidates and support a diverse portfolio of early exploratory and drug-discovery stage projects. Your expertise and leadership will be instrumental in driving our mission forward and making a significant impact in the field of aging/rejuvenation biology and drug discovery.

Responsibilities

• Develop and optimize cellular and biochemical assays to support our understanding of the deep mechanistic biology of rejuvenation/aging.
• Implement in vitro pharmacology strategies to validate targets and elucidate mechanisms of action for potential drug candidates.
• Collaborate with Institute of Science (IOS) labs and cross-functional teams to identify and validate novel drug targets.
• Work closely with process development and analytical development teams in Technical Operations to discover processes and assays that will align with their downstream operations.
• Provide scientific leadership and expertise in the field of aging/rejuvenation biology.
• Drive data analysis and interpretation to guide decision-making processes.
• Support a diverse portfolio of early exploratory and drug-discovery stage projects.
• Stay abreast of the latest scientific and technological advancements in the field.

Qualifications

• PhD in Pharmacology, Biology, Biochemistry, or a related field and a minimum of 3 years of industry experience in leading in vitro research in a drug discovery and development setting.
• Ability to think independently to design experiments and generate robust, reproducible, and generalizable results.
• Proven track record of solving complex biological mechanisms.
• Extensive experience in cellular or biochemical assay development with a background in relevant laboratory techniques and methods.
• Record of high productivity and ability to complete work in a timely manner.
• Proficient in documenting experimental design, analysis and interpretation of data in an ELN
• Excellent communication and presentation skills.

Preferred Qualifications

• Expertise in brightfield and confocal microscopy techniques and experience with high-content screening instruments and image analysis.
• Cell engineering for the development of cellular models and reporter assays.
• Experience working across diverse therapeutic modalities, including small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy is highly desirable.
• Experience working on cellular models of diverse age-related conditions is desirable, including metabolic, musculoskeletal, immune-related as well as cardiovascular and neurodegenerative diseases.
• Strong experience in the field of aging/rejuvenation biology.

Scientist I salary range is $121,550-$164,450

Scientist II salary range is $143,000-$220,780

Senior Scientist salary range is $166,000-$268,800

Exact compensation may vary based on skills, experience, and location.