Scientist/Senior Scientist, Bioanalytical Sciences

About Voyager Therapeutics 
Voyager Therapeutics (Nasdaq: VYGR) is a biotechnology company dedicated to breaking through barriers in gene therapy and neurology. The potential of both disciplines has been constrained by delivery challenges; Voyager is leveraging cutting-edge expertise in capsid discovery and deep neuropharmacology capabilities to address these constraints. Voyager’s TRACER™ AAV capsid discovery platform has generated novel capsids with high target delivery and blood-brain barrier penetration at low doses, potentially addressing the narrow therapeutic window associated with conventional gene therapy delivery vectors. This platform is fueling alliances with Pfizer Inc., Novartis Pharma AG, Neurocrine Biosciences, Inc., and Sangamo Therapeutics, Inc., as well as multiple programs in Voyager’s own pipeline. Voyager’s pipeline includes wholly owned and collaborative preclinical programs in Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and other diseases of the central nervous system, with a focus on validated targets and biomarkers to enable a path to rapid potential proof-of-biology. For more information, visit www.voyagertherapeutics.com.

Voyager Therapeutics® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc.

Job Summary:

Voyager Therapeutics is growing!  As part of our ongoing expansion, we are seeking an initiative-taking and experienced Scientist / Senior Scientist to join our Bioanalytical Sciences team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a desire to innovate and with a strong background in the development of cell lines, cell-based assays, and molecular biology techniques relevant to AAV Gene Therapy and Therapeutic Antibodies. This is a hands-on bench level position.

Key Responsibilities:

• Develop and execute cell-based assays utilizing primary, stable, or transformed cells
• Generate stable clonal cell lines using efficient gene-editing and/or knock out techniques
• Develop and execute molecular and biochemical assays to assess distribution, expression, and pharmacodynamic effects of AAV gene therapy candidates in vivo
• Participate in serum sample analysis for the measurement of anti-AAV TAb and NAb levels
• Identify and collect CNS tissue structures at the gross anatomical level for subsequent analyses
• Independently analyze data and present in various team formats
• Collate various bioanalysis data and author study report
• Integrate and collaborate with internal research teams in a challenging environment
• Lead and / or actively participate in the development of macros based on Excel, GraphPad Prism, and other software packages to facilitate data analysis, storage, and retrieval
• Transfer bioanalytical methods to CRO labs and monitor method validation and GLP / GCP sample analyses in those labs

Qualifications

• Bachelor’s or Master’s degree in Molecular / Cellular Biology, Biochemistry or a similar field with 8+ years, or PhD with relevant experience
• Expertise in the generation of cell lines and have superior cell culture skills
• Experience in development of cell-based assays
• Expertise in diverse molecular assay platforms (e.g., various PCR-based techniques)
• Independently motivated, meticulous scientist with critical thinking and problem-solving skills
• Excellent people skills including written and verbal communication
• Working in a collaborative and matrixed team environment
• Proficiency with Excel, SoftMax Pro, GraphPad Prism, JMP, or similar software

Preferred Experiences

• Experience various Ligand Binding Assay (LBA) formats
• Knowledge of neuroanatomy
• Knowledge of GLP and GCLP work environment
• Understanding of statistical principles as applicable in bioanalytical data analysis
• Experience in NGS, including RNA-seq analysis