Senior Analytical Development Scientist

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

We are seeking a senior scientist who will be responsible for developing, optimizing, and running our Mass Spectrometry workflows in Analytical Development. This scientist will play a key role in designing and executing MS methods for viral vector-based therapies. S/he will collaborate with other scientists to implement MS methods for AAV gene therapy product characterization and optimization of AAV platforms.

The scientist will:

• Develop and qualify protein characterization (intact mass, peptide mapping, post-translation modification analysis, sequent variant analysis) workflows for product characterization for pre-clinical and early clinical programs.
• Conduct experiments to support process development and platform development
• Be responsible for timely execution of experiments and interpretation of data
• Keep accurate, clear, and updated notebooks and records
• Help to maintain and troubleshoot MS and related equipment
• Provide input on design of new assays in Analytical Development and help to troubleshoot experiments
• Author and review technical reports and SOPs
• Collaborate with others within Research and Technology to support the pipeline progression.

Responsibilities

% of Time

Job Function and Description

50%

Working in the lab to execute experiments and troubleshooting experiments/equipment

35%

Design experiments, maintain notebooks, discuss and interpret data

10%

Preparation of presentations for group meetings

5%

Mandatory trainings and group meetings

Education and Experience Requirements

PhD in a relevant scientific discipline such as biological sciences, biochemistry, or analytical chemistry. Two to three years relevant biotech or pharmaceutical company experience required. Post-doctoral experience will be taken into consideration. Bachelor's or master's degree in a relevant scientific discipline with at least 3-5 years of related experience within an established biotech or pharmaceutical company.

Key Skills, Abilities, and Competencies

• Expertise with sample preparations for protein analysis by LC-MS.
• Expertise with enzymatic digests of proteins for peptide analysis by LC-MS.
• Expertise in liquid chromatography separations of proteins and peptides.
• Demonstrated hands-on experience with MS technologies (e.g., Q-TOF, Orbitrap, etc.) and their related system software (e.g., MassHunter, XCalibur)
• Hands-on experience with protein characterization data analysis applications (e.g., BioConfirm, ProteinMetrics Byos/Byosphere, etc.)
• Track record of assessing and implementing strategies to optimize protein identification and characterization workflows.
• Ability to work independently and assume ownership of experiments to drive results with minimal supervision.
• Strong analytical and problem-solving skills needed in order to design assays and experiments to answer complex analytical challenges
• Must be able to work in a collaborative manner in a team-based environment
• May provide guidance to more junior team members
• Familiarity with electrophoresis of proteins, proteomics workflows is a plus.

Complexity and Problem Solving

• Must be able to design solutions to complex analytical problems
• Plans, schedules, and arranges own activities to meet objectives
• Demonstrates good judgement in selecting methods/techniques for desired outcome
• Advanced skills in interpreting and synthesizing data and effectively communicating findings with some coaching from senior team members
• May refer to established procedures and guidelines

Internal and External Contacts

• May represent department as a prime contact on contracts or projects
• Interacts with senior internal/external personnel on significate matters often requiring coordination between organizations/departments/teams
• Interfaces with senior internal/external personnel in own area of expertise

Spark Therapeutics does not accept unsolicited resumes/candidate profiles from any source other than directly from candidates. Any unsolicited resume/candidate profile submitted through our website or to personal email accounts of employees of Spark Therapeutics are considered property of Spark Therapeutics and are not subject to payment of agency fees.