Senior Director Research Strategy and Operations (Core Team Leader – Liquid Biopsy)

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time actionable insights to physicians providing critical information about the right treatments for the right patients at the right time.

We are seeking an industry veteran to serve as the Core Team Leader (CTL) for our Liquid Biopsy (xF) portfolio.

In this high-impact role you will act as the “Leader of the Product Development Lifecycle." You will move beyond simple project coordination to assume full accountability for the execution and commercial launch of complex regulated diagnostic products. You will lead a cross-functional Core Team - comprising leaders from R&D Clinical Regulatory Quality Software and Operations - to navigate the journey from concept to commercialization.

This is a matrix leadership role. You will partner with a Product Manager (who defines market strategy) and a Project Manager (who manages tactical schedules) while you provide the strategic glue operational oversight and decision-making authority required to deliver the product to market.

• Serve as the single point of accountability for the development lifecycle ensuring the team delivers against the Target Product Profile (TPP) and Product Requirements.

• Lead a dedicated Core Team of functional heads (Science Engineering Quality Regulatory Lab Ops) without direct line authority. You must effectively negotiate priorities drive consensus among peers with competing incentives and align disparate groups toward a shared vision.

• Ensure the technical and clinical vision defined at the start of the project is consistently understood and executed across all technical sub-teams preventing scope creep or strategic drift.

• Proactively identify and resolve friction between functional groups (e.g. Commercial timelines vs. R&D feasibility). You will serve as the primary mediator fostering constructive debate to reach rapid data-driven decisions without needing constant escalation.

• Lead the product team through formal Stage-Gate Reviews (Phase Exits). You must possess the executive presence to synthesize complex technical clinical and operational data into clear actionable business narratives for the leadership team.

• Proactively identify critical path risks. You will drive difficult trade-off decisions between scope timeline and resources escalating structural blockers to the Executive Leadership Team only when necessary.

• Collaborate with functional leadership to ensure appropriate resource allocation ensuring the project aligns with the broader Tempus portfolio priorities.

• Champion a development process compliant with Design Control (21 CFR 820) and ISO 13485 standards. You will guide the team through the rigors of LDT 510(k) or PMA regulatory pathways.

• Oversee the critical transition from R&D to Clinical Lab Operations. You will ensure the "order-to-result" workflow is robust scalable and ready for commercial volume prior to launch.

• Act as the primary link between technical development and the Commercial organization ensuring that technical milestones translate into market-ready value propositions.

• Advanced degree (PhD MD MS) in Genetics Molecular Biology or Engineering required. MBA is a strong plus.

• 10+ years in the life sciences/diagnostics industry with at least 4+ years serving as a Core Team Leader Product Development Lead or Program Director in a matrixed environment.

• Deep experience in Oncology Diagnostics NGS or Liquid Biopsy is essential. Experience navigating FDA Class II/III medical device development (PMA/510k) is highly preferred.

• Expert knowledge of Phased-Gate/Stage-Gate development cycles. You understand the difference between tracking a timeline and leading a product to market.

• High emotional intelligence and communication skills required to manage up to executive level  stakeholders. You act as the "single source of truth" filtering noise and delivering clarity.

• Demonstrated ability to influence without authority. You can motivate and guide senior functional experts who do not report to you maintaining momentum even when faced with organizational ambiguity.

• Ability to "speak the language" of both the R&D scientists developing the chemistry and the Commercial leaders selling the test.

• You don't just focus on the science; you focus on the manufacturability and operational scalability of the test.

• Efficiency and success rate of Stage-Gate (Phase Exit) presentations to the Executive Committee.

• Adherence to the roadmap timeline while ensuring Design Control compliance.

• Seamless transfer to Operations with met KPIs for Turnaround Time (TAT) and success rates upon launch.

• High engagement and clarity scores from cross-functional Core Team members evidenced by reduced cross-departmental friction and unified project execution.

At Tempus AI we believe the future of medicine lies at the intersection of science and data. In this role you will be at the center of that evolution transforming how liquid biopsy and xF diagnostics provide clarity to clinicians and better outcomes for patients.

Pay Range: $192000 - $264000 USD

The expected salary range above is applicable if the role is performed from California and may vary for other locations (Colorado Illinois New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits which may include incentive compensation restricted stock units medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race religion color national origin gender sexual orientation age marital status veteran status or disability status. 

What We Do

We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time connect patients with therapies and clinical trials and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology neurology psychiatry cardiology and beyond—transforming how care is delivered and therapies are developed. At Tempus every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information visit tempus.com.

Why Work With Us

We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.

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