Senior Research Associate, Bioanalytical

Company Overview
Kisbee Therapeutics is an early-stage, venture-backed biotech startup that is targeting apolipoproteins to develop novel therapeutic agents for neurodegenerative diseases. Our mission is to translate genetic and biochemical insights into therapies that promote brain health and repair.

Position Summary
We are seeking a technical biomarker/bioanalytical scientist who has strong experience with the development and validation of biomarker, cell-based, immunogenicity, immuno- enzymatic, and/or chromatographic assays for support of preclinical, clinical and product release studies. This laboratory-based role will focus on the design, development and implementation of both fluid biomarker and bioanalytical ligand binding assays (e.g. ELISA, ECL detection, Quanterix) in biological matrix (plasma, serum, CSF, tissue lysate) to measure compound concentration, detect the presence of anti-drug antibody and neutralizing anti product antibody activity.  Experience with development and validation of LC/MS assays is a plus. This is a fantastic career opportunity within an early-stage company to help shape the development of disruptive and ground-breaking technology with the promise to change the course of neurodegenerative disease for millions of patients.

Key Responsibilities

• Development of bioanalytical and biomarker ligand-binding assays, including processing and analysis of large molecules (proteins, mRNA, etc.). This role will primarily support the execution of LBA assays in supporting of our nonclinical and clinical studies
• Work closely with other departments to establish the timelines of each project
• Independently plan, execute, and report routine sample analysis within group timelines
• Monitor and review data, qualification plans and reports, and bioanalytical plans and reports internally as well as outsourced to CRO’s
• Ensure data and documentation quality

Experience and Qualifications

• M.S. or B.S. in Biology, Bioengineering, Biochemistry, or related field with 3+ years of biotech/pharma industry experience
• Strong assay development and troubleshooting experience, including LLOQ optimization and non-specific binding matrix effects
• Experience with MSD, Quanterix, rtPCR instrumentation is a plus
• Exhibit independence, enthusiasm, openness, and adaptability
• MSD workbench, softMAX pro, Watson LIMS, JMP, Graphpad Prism preferred
• Attention to detail and strong communication skills are required
• Ability and desire to work in a collaborative environment
• Passion for curing neurodegenerative diseases is a plus
• The candidate must thrive in a fast-paced, dynamic environment with high expectations
• Integrity, quality, ability to troubleshoot issues, creative, bold, curiosity, collaborative spirit, respect for people, exemplary work ethic and setting the bar high are key values at Kisbee

At Kisbee, we believe that great teams are built on a foundation of kindness, honesty, and balance. New ideas and innovation fuel us, science and data guide us, and novel challenges and opportunities bring out our best. We work hard but recognize that we all have lives outside the lab and office. Join us, and together we will redefine the way we treat neurodegenerative disease.
 
Job Type: Full-time
 
Salary: Commensurate with role and experience
 
Kisbee Therapeutics is an Equal Opportunity Employer and does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other characteristic protected by applicable law.