Senior Scientist, Translational Immunology

Job Description

About This Role

HI-Bio, Inc., a Biogen company, is seeking an experienced Senior Scientist to help drive our biomarker and translational immunology strategies across several therapeutic programs in multiple indications. Translational Immunology at HI-Bio investigates the molecular pathways of disease to build upon our understanding of the mechanism of action of our therapeutics. The role is highly collaborative and provides translational science and cellular immunology expertise to inform both preclinical and clinical stage therapeutic programs. The successful candidate will be highly motivated, be able to think strategically and creatively, and be able to work independently to investigate novel biology of our therapeutics and their effect on immune cells in the context of severe immune-mediated diseases. This position will report to Principal Scientist in Translational Immunology.

What You’ll Do

• Lead translational research projects to inform the mechanism of action of our therapeutics and address key evidence gaps
• Independently design experiments, perform laboratory benchwork, analyze and interpret data, and clearly communicate complex results to cross-functional teams within the organization and externally
• Develop clinically relevant in vitro, ex vivo, and in vivo model systems to interrogate the effect of our therapeutics
• Responsible for flow cytometry-based biomarker assays in clinical studies including assay development, assay validation/qualification, outsourcing to specialty lab(s), data monitoring and reporting, and data analysis and interpretation
• Contribute to the development of biomarker strategies focused on generation of clinical evidence of immune target/pathway engagement and modulation of disease biomarkers
• Serve as the subject matter expert on the application of immunological techniques and model systems to drug development programs and contribute to asset clinical development plans
• Evaluate state-of-the art single cell technology platforms and guide implementation in translational research projects and clinical studies
• Work with cross-functional teams including discovery research, biomarker, clinical, biostatistics, and bioinformatic scientists
• Contribute to the preparation of study reports and summaries required for primary research publications, patent filings, and/or regulatory documents
• Participate in conferences and academic partnerships in the primary research area

This position is Hybrid based and travel to our San Francisco office on a regular basis. Candidates must be within a commutable distance to be considered.

Qualifications

Who You Are

You are a creative and inquisitive scientist with strong scientific training who can move forward projects aimed at uncovering novel biology of therapeutics.

Required Skills

• PhD in Immunology or related field with minimum 2+ years of relevant industry experience. BS/MS with 6+ years of relevant industry experience may be considered.
• Expertise in in vitro/ex vivo cell-based techniques including isolation of primary human immune cell subsets, mammalian cell culture, cell-based functional assays and multiparameter flow cytometry (10+ colors)
• Proficiency in flow cytometry software (FACSDiva, SpectroFlo, FlowJo, etc), GraphPad Prism, and Microsoft Office programs
• Strong scientific publication record in the field of immunology or related field
• Excellent oral, presentation, and written communication skills
• Ability to manage and prioritize multiple projects simultaneously
• Proven ability to work collaboratively in a team-oriented environment

Preferred Skills

• Strong track record of industry experience in applying immunological techniques to drug development
• Knowledge of and experience with in vivo autoimmune models preferred

Additional Information

HI-Bio, Inc. is a Biogen company based in South San Francisco, California. As of July 2, 2024, we are part of Biogen’s global team, with a commitment to excellence and a pioneering spirit. As part of a mid-sized biotechnology company, we offer the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission: Caring Deeply, Achieving Excellence, Changing Lives. 

Our team in San Francisco is specifically focused on transforming the lives of patients with severe immune-mediated diseases by developing novel targeted therapies with outsized clinical impact, faster. To accomplish this, we are seeking top talent to join us on our journey. 

The base compensation range for this role is $121,000 - $175,500. Base salary is determined by a combination of factors including, but not limited to, job related years of relevant experience, internal equity, and location of the job. Additionally, this role is eligible for participation in Biogen’s LTI grants and other incentive programs. Biogen offers a full range of benefits that include medical, dental, life, long and short-term disability insurances, vacation, end-of-year shutdown, and 401K participation and matching contributions. 

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.