Senior Scientist/Manager, Next Generation Platform Development Lead

How you’ll make an impact:

Independently lead the Innovation team to drive multiple projects, collaborate with other CPD group leads to manage CPD common technical/operational issues, resource prioritization, and staff career development. This is a chance to bring your in-depth T cell biology and process development experience as well as leadership acumen to drive scientific advancements in the T cell therapy process development field. 

About the team:

2seventy bio’s Cellular Process Development (CPD) team is a group in the Process and Analytical Development Department within Technical Development, Supply and Quality organization developing and characterizing processes to manufacture high-quality T cell therapies as drug products for our patients. We develop and characterize the cell therapy manufacturing platforms and chaperone them from pre-clinical to commercial manufacturing phases in collaboration with other teams across Process and Analytical Development, Manufacturing, Quality and Research. Come join our incredibly talented team and learn more about how the work from this team has a significant impact in patient’s lives.

How you’ll spend your time:

·       This is a leadership role!

·       Drive the next-generation manufacturing platform development for cell therapy and implementing advanced T cell culture technologies

·       Represent 2seventy bio and/or CPD group to lead technical discussions and foster decision-makings and collaborations with internal cross-functional teams or external partners

·       Manage a team of 4-6 Associate Scientists to Scientists in delivering the innovation projects and/or pipeline programs

·       Independently designing and managing laboratory experiments involving primary human immune cell isolation (PBMCs and T cells), genetic modification, T cell expansion, and cryopreservation

·       Design and perform analytical testing (e.g., multi color flow cytometry panels) to characterize T cell drug products and process performance

·       Apply statistical and data visualization techniques to interpret and report scientific data

·       Perform administrative duties including personnel and lab operations scheduling

·       Mentor junior scientists in both scientific applications and career development

·       Author, review, and maintain accurate and up to date records including experimental databases, production batch records, laboratory notebooks, quality facing reports, technology transfer documentation, and regulatory documentation

·       Hands-on lab-based position (50%) requiring a flexible schedule based on experimental work (some weekend work may be required depending on experiments occurring over >5 days).

Who you are and what you’ve accomplished:

·       MS or PhD in biomedical/biological engineering, chemical engineering, cell biology, immunology, or related discipline with 3-6 (PhD) or 7-10 (MS) years of industry experience, preferably in the cell therapy field

·       Experienced with novel and advanced T cell manufacturing technologies, such as Prodigy, is highly desirable

·       Prior managerial experience or cross-functional leadership experience is required

·       Direct experience with mammalian cell culture, preferably in T-flasks, static expansion bags, stirred tank reactors, and/or rocking bioreactor platforms, with a strong understanding of general laboratory techniques related to tissue culture and bioprocessing

·       Direct experience with biological assays such as via flow cytometry

·       Excellent organizational, time management, and interpersonal skills; Capable of multi-tasking and prioritization under shifting business needs and in highly matrixed teams

·       Knowledge of statistical analysis, data visualization, and design of experiments (DoE); Preferred experience in JMP and Prism software

·       Willingness to work with lentiviral vector and human biological samples such as primary human cells

·       Working knowledge of Microsoft Office suite, sufficient to author, review, revise, and present scientific data and/or reports

·       Attention to detail, demand for high-quality work, and sense of passion and urgency to achieve goals and improve the lives of patients

·       Looking to solve difficult, messy problems like developing cell therapies for cancer—it’s hard!

·       Ability to communicate above and below level in a way that fosters relationship building, including cross-functional teams, and external relationships with vendors

·       Successfully worked in a collaborative team environment where results are achieved through influence and incorporating multiple points of view

·       Excellent attention to detail, project and time management skills, and the ability to manage multiple priorities

·       Embraces and models our core values—re-think, have heart, better 2gether, time is now