Senior/Principal RA, Scientist, Protein Analytics

Senior/Principal RA, Scientist, Protein Analytics

Dragonfly Therapeutics seeks a scientist who brings enthusiasm, intellectual curiosity, scientific rigor, and a desire to help drive novel immunotherapy programs. The candidate must be independent, goal-oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic and innovative individuals with a deep scientific interest in immunotherapy and drug discovery, who thrive in a fast-paced, entrepreneurial environment.

Responsibilities:

• Provide protein mass spectrometry support of antibodies, TriNKETs, and recombinant proteins, including intact mass, peptide mapping, post-translational modification identification, and de novo sequencing
• Support developability studies by identifying and quantifying the chemical modification of amino acids
• Previous experience with Thermo and Waters mass spectrometers and Protein Metrics data analysis software is highly desired
• Provide biophysical and biochemical characterization support to inform lead candidate selection
• Interpret results and communicate with cross-functional colleagues and external partners for successful execution/completion of project
• Prepare technical reports, internal and external presentations
• Identify, evaluate, and implement new and existing mass spectrometry-based technologies to improve protein characterization capabilities, throughput, and quality
• Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks
• Prepare reagents, buffers, and equipment as needed to support experiments

Qualifications:

• Ph.D. in Chemistry, Biochemistry, Biochemical Engineering, or equivalent related fields with 0-2 years relevant industry experience or B.S. / M.S. with 5+ years’ relevant industry experience.
• Strong hands-on experience in protein mass spectrometry.
• Experience with characterization of proteins with techniques such as DSF, DSC, SEC-MALS, DLS/SLS, CE, cIEF, HPLC-based assays (SEC, HIC, IEX, etc.) is desirable.
• The candidate should be self-motivated, accountable, inquisitive, and have excellent organization and communication skills