Sr. Scientist, Analytical Development (Carbohydrates/Conjugates)

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

Looking for an energetic and talented individual to join our Analytical Development team. Primary responsibility for the incumbent will be to support the developmental activities currently on going in the laboratory as assigned.

Essential Functions:

• Provide strategic, tactical and technical leadership in the development of analytical methods for the purpose of characterizing drug product, drug substance, intermediates and critical raw material.
• Take on end-to-end responsibility of method development for characterization of proteins, bacterial polysaccharides, polysaccharide-protein conjugates, and adjuvanted vaccines product. Responsibility also includes resource planning, team productivity and timeline management of the deliverables.
• Drive analytical innovation and stay on top of cutting-edge analytical technology. Introduce and establish novel technology in house if necessary.
• Provide technical direction, mentorship and coaching to the analytical characterization team.
• Manage performance and development of personnel (2-4) to ensure achievement of organizational and department goals.
• Collaborate with Formulations and Process Development to provide analytical solutions for process understanding, troubleshooting and characterization.
• Author technical reports and analytical method.
• Cultivate a cohesive, innovative, nimble, and productive team environment.

Requirements:

• PhD in Chemistry, Analytical Chemistry, Biochemistry, or related field with 5+ years relevant industry experience; MS or BS with 8+ years of industry experience in Pharma /Biotech industry required.
• Proven leadership skills.
• Outstanding organization and planning skills.
• Must be a strong scientific leader who can guide scientists with clear goals of developing analytical methods, and critically and skillfully review and assess analytical methods under development. May need to provide direction for troubleshooting various issues during method development.
• Proven track record of analytical development leadership for biologics and small molecules, experience with vaccines, carbohydrate, or conjugates is a plus.
• Extensive expertise in U/HPLC, IC, colorimetric assays, mass spectrometry, and other analytical technologies as applied to protein analytical method development, trouble shooting and validation for GMP release and stability testing.
• Experience in carbohydrate and conjugates analysis is highly desired, for example in HPAEC-PAD, HPLC/UV/DAD/FLD, SEC-MALS, and colorimetric assays.
• Attention to detail and excellent skills in record keeping / documentation. Critical thinking and ability to analyze data.
• Strong interpersonal skills; ability to communicate effectively both verbally and in written formats.
• Ability to work with minimum supervision in a fast-paced, cross-functional environment and collaborate effectively with other team members. Eagerness and ability to learn and understand new concepts with ease.

Reports to: Associate Director, Analytical Development

Location: San Carlos, CA

Compensation:

The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range: $152,000 – $170,000

Send resumes to:

[email protected]

Vaxcyte, Inc.

825 Industrial Road, Suite 300

San Carlos, CA 94070

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.