Sr. Scientist - Bioanalysis, Product Development

The Organization

What’s happening at Entrada Therapeutics? Our mission is to transform the treatment of devastating diseases and improve patients’ quality of life through intracellular therapeutics. Leveraging our proprietary Endosomal Escape Vehicle (EEV)TM platform, we are advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, immunological, ocular and metabolic diseases, among others.

Our novel approach to drug design and delivery addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the field of intracellular therapeutics.

We’re a tight-knit team of experts and leaders in both therapeutics development and rare diseases and are excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Fit

You should be versatile, self-motivated, timeline and progress oriented, and looking forward to rolling up your sleeves, as you’ll be a member of the product development team. You will be managing and leading the bioanalytical aspects to support various modalities including oligonucleotides and proteins, to perform quantitative bioanalysis in complex biological matrices, and to actively explore, investigate and implement innovative technologies to facilitate program progress. You’ll be mentoring junior team members and supervising their day-to-day operations and developments. You’ll thrive in our team by leading internal efforts as well as managing CRO activities to provide timely bioanalytical support for pre-IND and IND enabling studies. You’ll have the opportunity to contribute to scientific publications and regulatory submissions as needed.

You should also enjoy a fast-paced environment and juggling competing priorities. You follow up and follow through, connecting problems with solutions efficiently. You work successfully in a team environment with strong interpersonal skills to effectively build working relationships inside and outside the company.

The Opportunity

Work within the bioanalytical team to enable the full spectrum of EEV-derived modalities development from early discovery candidate selection to late-stage process development.

Responsibilities

• Ability to design, develop, qualify and execute ligand binding assays (LBAs) including ELISA and ECL-based assays for PK/BD, biomarkers, ADA in various biological matrices (plasma, CSF, urine, and tissues, etc.) to support preclinical and clinical studies.
• Lead team members to support method development, qualification and transfer to advance Entrada pipelines.
• Lead in-house sample analysis and interpret/deliver high-quality data to support non-GLP studies (PK/ADME), and present results in team meetings.
• Investigate and implement other cutting-edge platforms outside field of expertise to meet challenging program needs.
• Manage non-GLP and GLP bioanalytical activities at CRO partners; provide scientific guidance and technical support on method transfer/development, qualification/validation, and sample analysis at CROs.
• Mentor and train junior scientists/associates.
• Manage both internal and external timelines for bioanalytical support to meet program timelines, communicate and work with stakeholders in a timely manner to avoid any delays.
• Write and review protocols and bioanalytical sections to be included in regulatory filings; understand regulatory requirements for GLP bioanalysis

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• PhD in chemistry, biochemistry, pharmacology, analytical chemistry, or a related field with 4+ years of post-doctoral experience; or a master’s degree with 8+ years of experience.
• Demonstrated leadership skills and project management experience. Experience of managing direct reports is required.
• Demonstrated knowledge and experience with LBAs and immunoassay development and qualification are required.
• Proficiency in common immunoassay platforms (ELISA, MSD, Luminex, etc.)
• Demonstrated experience in handling and preparation/purification of biological samples (urine, plasma, tissue, etc.).
• Ability to work independently in a fast-paced environment, as well as in a cross-collaborative team setting.
• Excellent communication skills (oral and written) and a track record of cross-disciplinary collaboration.
• Experience with oligonucleotide hybridization assays is highly desirable.
• Knowledge of pharmacokinetics and drug metabolism is desirable.
• Knowledge and experience with regulatory guidance and GLP bioanalysis is desirable.
• Experience with LC-MS/MS assays is desirable.

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.